Results 41 to 50 of about 6,219 (219)

Intra-axonal mechanisms driving axon regeneration

Brain Research, 2020
Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate.
Terika P, Smith, Pabitra K, Sahoo, Amar N, Kar, Jeffery L, Twiss   +3 more
openaire   +3 more sources

Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms

Neural Regeneration Research, 2015
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent a promising young-state stem cell source for cell-based therapy. hUCMSC transplantation into the transected sciatic nerve promotes axonal regeneration and functional recovery.
Zhi-yuan Guo, Xun Sun, Xiao-long Xu, Jiang Peng, Yu Wang   +4 more
doaj   +1 more source

SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity

Nature Communications
During peripheral nerve (PN) development, unmyelinated axons (nmAs) tightly fasciculate before being separated and enveloped by non-myelinating Schwann cells (nmSCs), glial cells essential for maintaining nmA integrity. How such a switch from axon-axon to axon-glia interactions is achieved remains poorly understood.
Li Liu, Zhigang Gao, Xueyuan Niu, Hong Yu, Xiaolong Xin, Yanlan Gu, Genghai Ma, Yan Gu, Yijun Liu, Sanhua Fang, Till Marquardt, Liang Wang   +11 more
openaire   +2 more sources

Flamingo Regulates R8 Axon-Axon and Axon-Target Interactions in the Drosophila Visual System [PDF]

Current Biology, 2003
Photoreceptors (R cells) in the Drosophila retina connect to targets in three distinct layers of the optic lobe of the brain: R1-R6 connect to the lamina, and R7 and R8 connect to distinct layers in the medulla. In each of these layers, R axon termini are arranged in evenly spaced topographic arrays. In a genetic screen for mutants with abnormal R cell
Senti, K A, Usui, T, Boucke, K, Greber, U F, Uemura, T, Dickson, B J   +5 more
openaire   +5 more sources

Axon and Myelin Morphology in Animal and Human Spinal Cord

Frontiers in Neuroanatomy, 2017
Characterizing precisely the microstructure of axons, their density, size and myelination is of interest for the neuroscientific community, for example to help maximize the outcome of studies on white matter (WM) pathologies of the spinal cord (SC).
Ariane Saliani, Blanche Perraud, Tanguy Duval, Nikola Stikov, Nikola Stikov, Serge Rossignol, Julien Cohen-Adad, Julien Cohen-Adad   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Neuronal Dynamics and Axonal Flow: Axonal Peristalsis [PDF]

Proceedings of the National Academy of Sciences, 1972
By time-lapse, phase-contrast cinemicrography of sensory nerve fibers of young mice, isolated with their originating spinal ganglia in nutrient solution, the postulated peristaltic surface drive of the cellulifugal propulsion of the semisolid axonal column at a rate of the order of 1 mm/day (1 μm/min) could be verified and quantitatively analyzed.
openaire   +2 more sources

microRNAs in axon guidance [PDF]

Frontiers in Cellular Neuroscience, 2014
Brain wiring is a highly intricate process in which trillions of neuronal connections are established. Its initial phase is particularly crucial in establishing the general framework of neuronal circuits. During this early step, differentiating neurons extend axons, which reach their target by navigating through a complex environment with extreme ...
Iyer, A. N., Bellon, A., Baudet, M. L.
openaire   +3 more sources

Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

Biology Open, 2019
The distribution of assembled, and potentially translating, ribosomes within cells can be visualised in Drosophila by using Bimolecular Fluorescence Complementation (BiFC) to monitor the interaction between tagged pairs of 40S and 60S ribosomal proteins (
Anand K. Singh, Akilu Abdullahi, Matthias Soller, Alexandre David, Saverio Brogna   +4 more
doaj   +1 more source