Results 51 to 60 of about 228,091 (312)
Intra-axonal mechanisms driving axon regeneration
Brain Research, 2020 Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate.
Terika P, Smith +3 more
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Axon degeneration: Linking axonal bioenergetics to myelin [PDF]
Journal of Cell Biology, 2016 The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0 and describe a number of early axonal ...
Beirowski, Bogdan +2 more
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Metabolic reprogramming: a new option for the treatment of spinal cord injury
Neural Regeneration ResearchSpinal cord injuries impose a notably economic burden on society, mainly because of the severe after-effects they cause. Despite the ongoing development of various therapies for spinal cord injuries, their effectiveness remains unsatisfactory. However, a
Jiangjie Chen +13 more
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The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish
Frontiers in Molecular Neuroscience, 2020 Sex-determining region Y box 2 (Sox2), expressed in neural tissues, plays an important role as a transcription factor not only in the pluripotency and proliferation of neuronal cells but also in the opposite function of cell differentiation. Nevertheless,
Jie Gong +12 more
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Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons
mBio, 2023 Herpes simplex virus-1 (HSV-1) has evolved mechanisms to evade the host immune system and limit the antiviral effects induced by interferon (IFN) produced by local epithelial and immune cells.
Kevin Danastas +6 more
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Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons [PDF]
, 2009 Huntington's Disease is a neurodegenerative condition caused by a polyglutamine expansion in thehuntingtin (Htt) protein, which aggregates and also causes neuronal dysfunction. Pathogenic N-terminal httfragments perturb axonal transport in vitro.
Burbidge-King, T. +13 more
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Mistargeted axons are selectively retracted.
, 2023 zCrest:GFP labels axons that project only to the abductor muscle prior to axon injury, whereas Tubb:dsRed labels all axons. The timelapse begins at 10 hpt with 15-min intervals. In the first part, axon growth onto the adductor muscle is shown.
Koichi Kawakami (128958) +3 more
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Neuronal Dynamics and Axonal Flow: Axonal Peristalsis [PDF]
Proceedings of the National Academy of Sciences, 1972 By time-lapse, phase-contrast cinemicrography of sensory nerve fibers of young mice, isolated with their originating spinal ganglia in nutrient solution, the postulated peristaltic surface drive of the cellulifugal propulsion of the semisolid axonal column at a rate of the order of 1 mm/day (1 μm/min) could be verified and quantitatively analyzed.
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Neuron Names: A Gene- and Property-Based Name Format, With Special Reference to Cortical Neurons
Frontiers in Neuroanatomy, 2019 Precision in neuron names is increasingly needed. We are entering a new era in which classical anatomical criteria are only the beginning toward defining the identity of a neuron as carried in its name.
Gordon M. Shepherd +14 more
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