The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog [PDF]
, 2006 We show that desert hedgehog ( dhh), a signaling molecule expressed by Schwann cells, is essential for the structural and functional integrity of the peripheral nerve.
Jessen, KR +6 more
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Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system [PDF]
, 2016 Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer’s disease.
Allan, Debbie +7 more
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Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. [PDF]
, 2010 Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal ...
Beattie, Michael S +13 more
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The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]
, 2017 The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J. +4 more
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Polybrominated diphenyl ethers perturb axonal growth and actin distribution
Bibechana, 2018 We investigated toxicological effects of two of the most common polybrominated diphenyl ether (PBDE) flame retardants, BDE-47 and BDE-209, in model PC12 cell line under two environmentally relevant exposure conditions: long term exposure to microgram ...
Bhanu B Neupane +4 more
doaj +1 more source
Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]
, 2017 Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G. +4 more
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Axonal growth arrests after an increased accumulation of Schwann cells expressing senescence markers and stromal cells in acellular nerve allografts [PDF]
, 2016 Acellular nerve allografts (ANAs) and other nerve constructs do not reliably facilitate axonal regeneration across long defects (>3 cm). Causes for this deficiency are poorly understood.
Ee, Xueping +11 more
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Frontiers in Computational Neuroscience, 2020 Advances in computation and neuronal modeling have enabled the study of entire neural tissue systems with an impressive degree of biological realism. These efforts have focused largely on modeling dendrites and somas while largely neglecting axons.
Clayton S. Bingham +5 more
doaj +1 more source
Optimal sizes of dendritic and axonal arbors in a topographic projection
, 1999 I consider a topographic projection between two neuronal layers with different densities of neurons. Given the number of output neurons connected to each input neuron (divergence) and the number of input neurons synapsing on each output neuron ...
Chklovskii, Dmitri B.
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Rule learning enhances structural plasticity of long-range axons in frontal cortex. [PDF]
, 2016 Rules encompass cue-action-outcome associations used to guide decisions and strategies in a specific context. Subregions of the frontal cortex including the orbitofrontal cortex (OFC) and dorsomedial prefrontal cortex (dmPFC) are implicated in rule ...
Johnson, Carolyn +3 more
core +3 more sources