Results 61 to 70 of about 224,860 (308)

Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration [PDF]

, 2010
Background: Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons ...
Bernadette ZY Wong, Shokouhi, B.N., Lieberman, A.R., Tohyama, K., Wong Bernadette ZY, Campbell, G., Koujiro Tohyama, Anderson Patrick N, Gregor Campbell, Tohyama Koujiro, Campbell Gregor, Samir Siddiqui, Siddiqui, S., Patrick N Anderson, A Robert Lieberman, Bahman N Shokouhi, Wong, B.Z.Y., Shokouhi Bahman N, Anderson, P.N., Lieberman A Robert, Siddiqui Samir   +20 more
core   +1 more source

Lmx1b is required at multiple stages to build expansive serotonergic axon architectures

eLife, 2019
Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question
Lauren J Donovan, William C Spencer, Meagan M Kitt, Brent A Eastman, Katherine J Lobur, Kexin Jiao, Jerry Silver, Evan S Deneris   +7 more
doaj   +1 more source

Microchannels as Axonal Amplifiers

IEEE Transactions on Biomedical Engineering, 2008
An implantable neural interface capable of reliable long-term high-resolution recording from peripheral nerves has yet to be developed. Device design is challenging because extracellular axonal signals are very small, decay rapidly with distance from the axon, and in myelinated fibres are concentrated close to nodes of Ranvier, which are around 1 mum ...
James FitzGerald, Stéphanie P. Lacour, Stephen B. McMahon, James W. Fawcett   +3 more
openaire   +5 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons [PDF]

, 2003
Transplantation of olfactory ensheathing cells into spinal cord lesions promotes regeneration of cut axons into terminal fields and functional recovery.
Raisman, G., Li, D., Li, Y., Lund, R.D., Sauvé, Y.   +4 more
core  

Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]

, 1990
The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Kröger, Stephan, Nierhörster, L., S. Kroger, L. Niehorster, Kröger, S. ; https://orcid.org/, Niehörster, L.   +5 more
core   +1 more source

Activity-dependent excitability changes in normal and demyelinated rat spinal root axons [PDF]

, 1985
Myelinated nerve fibres with a reduced safety factor for conduction due to demyelination are easily blocked by trains of impulses. To find out why, in vivo recordings from rat ventral root fibres demyelinated with diphtheria toxin have been supplemented ...
Bostock, Hugh, Grafe, Peter
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Chick PTPσ regulates the targeting of retinal axons within the optic tectum [PDF]

, 2002
Chick PTP (cPTP), also known as CRYP, is a receptor-like protein tyrosine phosphatase found on axons and growth cones. Putative ligands for cPTP are distributed within basement membranes and on glial end feet of the retina, optic nerve, and optic tectum,
Aricescu, AR, Aricescu, Alexandru, Rashid-Doubell, F, McKinnell, I, Sajnani, G, Stoker, A   +5 more
core  

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source