Results 61 to 70 of about 228,091 (312)
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Flamingo Regulates R8 Axon-Axon and Axon-Target Interactions in the Drosophila Visual System [PDF]
Current Biology, 2003 Photoreceptors (R cells) in the Drosophila retina connect to targets in three distinct layers of the optic lobe of the brain: R1-R6 connect to the lamina, and R7 and R8 connect to distinct layers in the medulla. In each of these layers, R axon termini are arranged in evenly spaced topographic arrays. In a genetic screen for mutants with abnormal R cell
Senti, K A +5 more
openaire +5 more sources
Lmx1b is required at multiple stages to build expansive serotonergic axon architectures
eLife, 2019 Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question
Lauren J Donovan +7 more
doaj +1 more source
Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons [PDF]
, 2003 Transplantation of olfactory ensheathing cells into spinal cord lesions promotes regeneration of cut axons into terminal fields and functional recovery.
Raisman, G. +4 more
core
Commissural Axon Kinetics and the Role of Netrin in Early Brain Circuitry Development [PDF]
, 2005 As neurons begin to differentiate, they send out processes called axons to initiate the formation of functional nerve connections. A specialized structure at the end of an axon called the growth cone is believed to possess the impressive navigational and
Bak-Maier, Magdalena
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Microchannels as Axonal Amplifiers
IEEE Transactions on Biomedical Engineering, 2008 An implantable neural interface capable of reliable long-term high-resolution recording from peripheral nerves has yet to be developed. Device design is challenging because extracellular axonal signals are very small, decay rapidly with distance from the axon, and in myelinated fibres are concentrated close to nodes of Ranvier, which are around 1 mum ...
James FitzGerald +3 more
openaire +5 more sources
eLife, 2016 The mechanisms regulating synapse numbers during development and ageing are essential for normal brain function and closely linked to brain disorders including dementias. Using Drosophila, we demonstrate roles of the microtubule-associated protein Tau in
Andre Voelzmann +6 more
doaj +1 more source
Chick PTPσ regulates the targeting of retinal axons within the optic tectum [PDF]
, 2002 Chick PTP (cPTP), also known as CRYP, is a receptor-like protein tyrosine phosphatase found on axons and growth cones. Putative ligands for cPTP are distributed within basement membranes and on glial end feet of the retina, optic nerve, and optic tectum,
Aricescu, AR +4 more
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source