Visualisation of ribosomes in Drosophila axons using Ribo-BiFC
Biology Open, 2019 The distribution of assembled, and potentially translating, ribosomes within cells can be visualised in Drosophila by using Bimolecular Fluorescence Complementation (BiFC) to monitor the interaction between tagged pairs of 40S and 60S ribosomal proteins (
Anand K. Singh +4 more
doaj +1 more source
GABA increases electrical excitability in a subset of human unmyelinated peripheral axons [PDF]
, 2010 A proportion of small diameter primary sensory neurones innervating human skin are chemosensitive. They respond in a receptor dependent manner to chemical mediators of inflammation as well as naturally occurring algogens, thermogens and pruritogens.
Sittl Ruth +11 more
core +2 more sources
Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination
Frontiers in Neuroanatomy, 2021 Mitochondria are essential for neurons and must be optimally distributed along their axon to fulfill local functions. A high density of mitochondria has been observed in retinal ganglion cell (RGC) axons of an unmyelinated region of the optic nerve ...
Samantha J. Wilkison +10 more
doaj +1 more source
Is resistance to ischaemia of motor axons in diabetic subjects due to membrane depolarization? [PDF]
, 1990 The reasons for the resistance to ischaemia of peripheral nerves in diabetics are not well understood. We have now explored whether axonal depolarization underlies this phenomenon, as has previously been proposed.
Weigl, Paul +5 more
core +1 more source
Resveratrol promotes axonal regeneration via PI3K/Akt pathway in rats after intracerebral hemorrhage
Di-san junyi daxue xuebao, 2019 Objective To investigate the mechanism by which resveratrol (RES) promotes axonal regeneration in rats after intracerebral hemorrhage (ICH) and explore the role of the PI3K/Akt pathway that regulates the AMPKα pathway.
WANG Guanyu +4 more
doaj +1 more source
Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons [PDF]
, 2014 This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon +7 more
core +1 more source
Brain and Behavior, 2020 Introduction Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to span the gap between the stumps of ...
Jolanta Fertala +5 more
doaj +1 more source
Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation
eLife, 2022 In many eukaryotic cells, directed molecular transport occurs along microtubules. Within neuronal axons, transport over vast distances particularly relies on uniformly oriented microtubules, whose plus-ends point towards the distal axon tip ...
Maximilian AH Jakobs +2 more
doaj +1 more source
Molecular mechanisms separating two axonal pathways during embryonic development of the avian optic tectum [PDF]
, 1991 During embryonic development of the avian optic tectum, retinal and tectobulbar axons form an orthogonal array of nerve processes. Growing axons of both tracts are transiently very closely apposed to each other. Despite this spatial proximity, axons from
Kröger, Stephan +3 more
core +1 more source
eLife, 2019 Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C.
Yue Qu +11 more
doaj +1 more source