Results 31 to 40 of about 829,895 (308)

Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration [PDF]

, 2010
Background: Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons ...
Bernadette ZY Wong, Shokouhi, B.N., Lieberman, A.R., Tohyama, K., Wong Bernadette ZY, Campbell, G., Koujiro Tohyama, Anderson Patrick N, Gregor Campbell, Tohyama Koujiro, Campbell Gregor, Samir Siddiqui, Siddiqui, S., Patrick N Anderson, A Robert Lieberman, Bahman N Shokouhi, Wong, B.Z.Y., Shokouhi Bahman N, Anderson, P.N., Lieberman A Robert, Siddiqui Samir   +20 more
core   +1 more source

c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. [PDF]

, 2012
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy, Turmaine, Mark, Mirsky, Rhona, Quintes, Susanne, Wicher, GK, Chabrol, Elodie, Latouche, Morwena, Chabrol, E, Behrens, A, Mirsky, R, Woodhoo, Ashwin, Jenkins, B, Mitter, Richard, Quintes, S, Turmaine, M, Greensmith, L, Woodhoo, A, Mitter, R, Behrens, Axel, Raivich, Gennadij, Wicher, Grzegorz K.,, Latouche, M, Banerjee, Annbily, Arthur-Farraj, PJ, Wilton, DK, Banerjee, A, Rahman, Mary, Jessen, KR, Rahman, M, Greensmith, Linda, Raivich, G, Arthur-Farraj, Peter J., Wilton, Daniel K., Jessen, Kristjan R.   +33 more
core   +1 more source

Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush [PDF]

, 2007
Multiple molecular mechanisms influence nerve regeneration. Because serine proteases were shown to affect peripheral nerve regeneration, we performed nerve crush experiments to study synapse reinnervation in adult mice lacking the serpin protease nexin-1
Atanasoski, Suzana, Suter, Ueli, Kvajo, Mirna, Fayard, Bérengère, Moreno, Eliza, Lino, Maria Maddalena, Brenner, Hans Rudolf, Monard, Denis, Atanasoski S, Fayard B, Moreno E, Monard D, Lino MM, Suter U, Brenner HR, Kvajo M   +15 more
core   +1 more source

Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis

Frontiers in Molecular Biosciences, 2023
Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang, Tao Tang, Zhongyuan He, Zhongyuan He, Zhengya Zhu, Fuan Wang, Fuan Wang, Hongkun Chen, Fu Zhang, Jiaxiang Zhou, Jianmin Wang, Baoliang Li, Baoliang Li, Xizhe Liu, Zhiyu Zhou, Zhiyu Zhou, Shaoyu Liu, Shaoyu Liu   +17 more
doaj   +1 more source

Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease

Neurobiology of Disease, 2014
In Krabbe's disease (KD), a leukodystrophy caused by β-galactosylceramidase deficiency, demyelination and a myelin-independent axonopathy contributes to the severe neuropathology.
Carla Andreia Teixeira, Catarina Oliveira Miranda, Vera Filipe Sousa, Telma Emanuela Santos, Ana Rita Malheiro, Melani Solomon, Gustavo H. Maegawa, Pedro Brites, Mónica Mendes Sousa   +8 more
doaj   +1 more source

Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment

Cells, 2020
By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and ...
Ana Rita Costa, Monica M. Sousa
doaj   +1 more source

The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling

Frontiers in Molecular Neuroscience, 2018
In the adult nervous system axon caliber varies widely amongst different tracts. When considering a given axon, its diameter can further fluctuate in space and time, according to processes including the distribution of organelles and activity-dependent ...
Ana Rita Costa, Rita Pinto-Costa, Rita Pinto-Costa, Sara Castro Sousa, Mónica Mendes Sousa   +4 more
doaj   +1 more source

The Role of Spastin in Axon Biology

Frontiers in Cell and Developmental Biology, 2022
Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mounting body
Ana Catarina Costa, Ana Catarina Costa, Monica Mendes Sousa   +2 more
doaj   +1 more source

The Rate of Regeneration of Nerve [PDF]

Journal of Experimental Biology, 1942
ABSTRACT Five different methods have been used to estimate the rate of advance of regeneration along nerves in the rabbit. Not all give the same result. When the advance of the axon tips is studied a higher rate is recorded than when the times necessary for functional recovery are considered.
E. Gutmann, L. Guttmann, P. B. Medawar, J. Z. Young   +3 more
openaire   +2 more sources

What Are the Risk Factors for Adjacent Vertebral Fracture After Vertebral Augmentation? A Meta-Analysis of Published Studies

Global Spine Journal, 2022
Study Design: Meta-analysis. Objectives: To provide up-to-date evidence-based outcomes for the incidence and risk factors of adjacent vertebral fracture (AVF) after the vertebral augmentation.
Tianyu Zhang MD, Yanhua Wang MD, Peixun Zhang MD, Feng Xue MD, Dianying Zhang MD, Baoguo Jiang MD   +5 more
doaj   +1 more source