Results 51 to 60 of about 1,744,648 (406)

Identification of hub genes related to the innate immune response activated during spinal cord injury

FEBS Open Bio, 2022
Spinal cord injury (SCI) often leads to sensory and motor dysfunction. Two major factors that hinder spinal cord repair are local inflammation and glial scar formation after SCI, and thus appropriate immunotherapy may alleviate damage.
Jianfeng Li, Xizhe Liu, Huachuan Wu, Peng Guo, Baoliang Li, Jianmin Wang, Wei Tian, Dafu Chen, Manman Gao, Zhiyu Zhou, Shaoyu Liu   +10 more
doaj   +1 more source

Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration

Acta Pharmacologica Sinica, 2020
Peripheral nerve injury (PNI), one of the most common concerns following trauma, can result in a significant loss of sensory or motor function. Restoration of the injured nerves requires a complex cellular and molecular response to rebuild the functional
Rui Li, Duo-hui Li, Hong-Yu Zhang, Jian Wang, Xiao‐kun Li, Jian Xiao   +5 more
semanticscholar   +1 more source

Intradiscal injection for the management of low back pain

JOR Spine, 2022
Low back pain (LBP) is a common clinical problem and a major cause of physical disability, imposing a prominent socioeconomic burden. Intervertebral disc degeneration (IDD) has been considered the main cause of LBP.
Fu Zhang, Songjuan Wang, Baoliang Li, Wei Tian, Zhiyu Zhou, Shaoyu Liu   +5 more
doaj   +1 more source

Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation

Frontiers in Cell and Developmental Biology, 2021
Transthyretin (TTR), a plasma and cerebrospinal fluid protein, increases axon growth and organelle transport in sensory neurons. While neurons extend their axons, the microtubule (MT) cytoskeleton is crucial for the segregation of functional compartments
Jessica Eira, Jessica Eira, Joana Magalhães, Nídia Macedo, Maria Elena Pero, Maria Elena Pero, Thomas Misgeld, Mónica M. Sousa, Francesca Bartolini, Márcia A. Liz   +9 more
doaj   +1 more source

Peripheral Nerve Regeneration and Muscle Reinnervation

International Journal of Molecular Sciences, 2020
Injured peripheral nerves but not central nerves have the capacity to regenerate and reinnervate their target organs. After the two most severe peripheral nerve injuries of six types, crush and transection injuries, nerve fibers distal to the injury site
T. Gordon
semanticscholar   +1 more source

Endocannabinoid System Modulates Glial Responses and Motoneuron Preservation After Spinal Cord Ventral Root Axotomy

Neuroglia
Background/Objectives: Injuries to spinal ventral roots induce complex retrograde reactions that compromise motoneuron survival, synaptic organization, and glial responses, ultimately limiting the potential for regeneration.
Caroline Machado Tomazelli, Alexandre Leite Rodrigues de Oliveira, Luciana Politti Cartarozzi   +2 more
doaj   +1 more source

Quantitative analysis of cell types during growth and morphogenesis in Hydra [PDF]

, 1973
Tissue maceration was used to determine the absolute number and the distribution of cell types in Hydra. It was shown that the total number of cells per animal as well as the distribution of cells vary depending on temperature, feeding conditions, and ...
A. Gierer, A. L. Burnett, C. N. David, C. N. David, E. Trenkner, G. Webster, H. Bode, H. K. MacWilliams, H. Schaller, J. J. Kanaev, L. Wolpert, P. Tardent, P. Tardent, R. D. Campbell, S. Berking, T. L. Lentz, W. F. Loomis   +16 more
core   +1 more source

Combination of Adult Mesenchymal Stem Cell Therapy and Immunomodulation with Dimethyl Fumarate Following Spinal Cord Ventral Root Repair

Biology
Spinal cord injury results in significant motor and sensory loss. In the experimental ventral root avulsion (VRA) model, the ventral (motor) roots are disconnected from the spinal cord surface, disrupting contact between spinal motoneurons and muscle ...
Paula Regina Gelinski Kempe, Mateus Vidigal de Castro, Lilian de Oliveira Coser, Luciana Politti Cartarozzi, Benedito Barraviera, Rui Seabra Ferreira, Alexandre Leite Rodrigues de Oliveira   +6 more
doaj   +1 more source

Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury

Stem cell research & therapeutics, 2020
The development of new treatment strategies to improve peripheral nerve repair after injury, especially those that accelerate axonal nerve regeneration, is very important.
Jiuhong Zhao, Yali Ding, Rui He, Kui Huang, Lucinda S Liu, Chaona Jiang, Zhuozhou Liu, Yuanlan Wang, Xiaokai Yan, Fuyang Cao, Xueying Huang, Yanan Peng, Rui Ren, Yuebin He, Tian-wei Cui, Quanpeng Zhang, Xianfang Zhang, Qibing Liu, YunQing Li, Zhijian Ma, Xinan Yi   +20 more
semanticscholar   +1 more source

Flow Cytometry Characterization and Analysis of Glial and Immune Cells from the Spinal Cord

Neuroglia
Several protocols have been developed with the aim of characterizing glial and immune cells from the central and peripheral nervous systems. However, a small number of these protocols have demonstrated the ability to yield satisfactory results following ...
Lilian de Oliveira Coser, Manuela Tosi Comelis, Débora Elisa da Costa Matoso, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +4 more
doaj   +1 more source