Results 61 to 70 of about 1,744,648 (406)

Neuroscience of Peripheral Nerve Regeneration

Journal of Pharmacy and Bioallied Sciences, 2021
Peripheral nerve injury involves complex molecular, cellular, and genetic events that help in ultimate regeneration of nerve. Some key factors are upregulated and some downregulated in the process of regeneration of nerve to attain almost perfect architecture.
Sunil Paramel Mohan, Murugan Ramalingam
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study

Frontiers in Physiology, 2023
Background: Heterotopic ossification of tendons and ligaments (HOTL) is a common clinical condition characterized by the absence of discernible features and a lack of effective treatment. In vitro experiments have demonstrated that mechanical stimulation
Zhengya Zhu, Zhengya Zhu, Zhongyuan He, Zhongyuan He, Tao Tang, Tao Tang, Fuan Wang, Fuan Wang, Hongkun Chen, Jiaxiang Zhou, Chengkai Lin, Guoliang Chen, Jianmin Wang, Jianfeng Li, Xizhe Liu, Zhiyu Zhou, Zhiyu Zhou, Shaoyu Liu, Shaoyu Liu   +18 more
doaj   +1 more source

Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. [PDF]

, 2019
BackgroundNeurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are involved in vascular remodeling; however,
Hsueh, Yuan-Yu, Huang, Ching-Wen, Huang, Wen-Chin, Li, Song, Patel, Shyam   +4 more
core  

The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice [PDF]

, 2013
Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.
Cunningham, Madeleine E., Furukawa, Koichi, Rupp, Angie, Willison, Hugh J., Yao, Denggao   +4 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Immunomodulation by 4-Hydroxy-TEMPO (TEMPOL) and Dimethyl Fumarate (DMF) After Ventral Root Crush (VRC) in C57BL/6J Mice: A Flow Cytometry Analysis

Biology
Spinal motor nerve root lesions can happen after avulsion or crush, generating acute motoneuron death and synaptic loss, consequently, causing motor and sensory dysfunctions. Local response is mediated by astroglial and microglial cells, giving rise to a
Maria Fernanda Vannucci Balzani, Lilian de Oliveira Coser, Alexandre Leite Rodrigues de Oliveira   +2 more
doaj   +1 more source

Neuropeptides Involved in Facial Nerve Regeneration

Biomedicines, 2021
Neuropeptides and neurotransmitters act as intermediaries to transmit impulses from one neuron to another via a synapse. These neuropeptides are also related to nerve degeneration and regeneration during nerve damage.
Inhyeok Kim, Yonjae Kim, Daewoong Kang, Junyang Jung, Sungsoo Kim, Hwasung Rim, Sanghoon Kim, Seung-Geun Yeo   +7 more
doaj   +1 more source

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. [PDF]

, 2009
A principal objective of spinal cord injury (SCI) research is the restoration of axonal connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms would guide regenerating spinal cord axons to appropriate brainstem targets ...
Alto, Laura Taylor, Blesch, Armin, Conner, James M, Havton, Leif A, Hollis, Edmund R, Tuszynski, Mark H   +5 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source