Results 1 to 10 of about 3,422,495 (345)

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

Cell Metabolism, 2023
Summary The peripheral nervous system harbors a remarkable potential to regenerate after acute nerve trauma. Full functional recovery, however, is rare and critically depends on peripheral nerve Schwann cells that orchestrate breakdown and resynthesis of
Robert Fledrich, Theresa Kungl, Silvana Müller   +2 more
exaly   +2 more sources

Advances in biomaterial-based tissue engineering for peripheral nerve injury repair

Bioactive Materials
Peripheral nerve injury is a common clinical disease. Effective post-injury nerve repair remains a challenge in neurosurgery, and clinical outcomes are often unsatisfactory, resulting in social and economic burden.
Yanan Ji, Zihui Gao, Bingqian Chen
exaly   +2 more sources

Schwann cell functions in peripheral nerve development and repair.

Neurobiology of Disease, 2023
The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among the most multifaceted cells of the body. During development, SCs secure neuronal survival and participate in axonal path finding.
Mar Bosch-Queralt, R. Fledrich, R. Stassart   +2 more
semanticscholar   +1 more source

3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration

Advancement of science, 2023
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs.
Yong-Cong Fang, Chengjin Wang, Zi-Bo Liu, Jeonghoon Ko, Li Chen, T. Zhang, Zhuo Xiong, Lei Zhang, Wei Sun   +8 more
semanticscholar   +1 more source

Peripheral Nerve Injury Treatments and Advances: One Health Perspective

International Journal of Molecular Sciences, 2021
Peripheral nerve injuries (PNI) can have several etiologies, such as trauma and iatrogenic interventions, that can lead to the loss of structure and/or function impairment.
B. Lopes, P. Sousa, R. Alvites, M. Branquinho, A. Sousa, C. Mendonça, L. Atayde, A. L. Luís, A. Varejão, A. C. Maurício   +9 more
semanticscholar   +1 more source

Targeted muscle reinnervation and regenerative peripheral nerve interfaces for pain prophylaxis and treatment: A systematic review

PM & R : the journal of injury, function, and rehabilitation, 2023
Nerve pain frequently develops following amputations and peripheral nerve injuries. Two innovative surgical techniques, targeted muscle reinnervation (TMR) and regenerative peripheral nerve interfaces (RPNI), are rapidly gaining popularity as ...
J. Mauch, Dennis S. Kao, J. Friedly, Yusha Liu   +3 more
semanticscholar   +1 more source

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Nature Communications, 2022
Activation of microglia in the spinal cord following peripheral nerve injury is critical for the development of long-lasting pain hypersensitivity. However, it remains unclear whether distinct microglia subpopulations or states contribute to different ...
Shannon N Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain S Pacis, M. Parisien, Haley Deamond, Calvin Wong, O. Rabau, Nicole Brown, L. Haglund, J. Ouellet, Carlo Santaguida, A. Ribeiro-da-Silva, Soroush Tahmasebi, M. Prager-Khoutorsky, J. Ragoussis, Ji Zhang, M. Salter, L. Diatchenko, Luke M. Healy, J. Mogil, A. Khoutorsky   +22 more
semanticscholar   +1 more source

3D Printed Personalized Nerve Guide Conduits for Precision Repair of Peripheral Nerve Defects

Advancement of science, 2022
The treatment of peripheral nerve defects has always been one of the most challenging clinical practices in neurosurgery. Currently, nerve autograft is the preferred treatment modality for peripheral nerve defects, while the therapy is constantly plagued
Kai Liu, Lesan Yan, Ruo-Nan Li, Zhiming Song, Jian-Xun Ding, Bin Liu, Xue-Si Chen   +6 more
semanticscholar   +1 more source

The Effect of Electrical Stimulation on Nerve Regeneration Following Peripheral Nerve Injury

Biomolecules, 2022
Peripheral nerve injuries (PNI) are common and often result in lifelong disability. The peripheral nervous system has an inherent ability to regenerate following injury, yet complete functional recovery is rare.
Luke T. Juckett, T. Saffari, Benjamin H. Ormseth, J. Senger, Amy M. Moore   +4 more
semanticscholar   +1 more source

Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration

Advancement of science, 2022
Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting.
Zhi Yao, Weihao Yuan, Jian-Kun Xu, Wen-Xue Tong, Jie Mi, Pak-cheong Ho, D. Chow, Ye Li, Hao Yao, Xu Li, Shunxiang Xu, Jiaxin Guo, Qing-Tang Zhu, L. Bian, Ling Qin   +14 more
semanticscholar   +1 more source