Results 41 to 50 of about 674,907 (364)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Health-related quality of life in patients with peripheral nerve tumors: results from the German multicentric Peripheral Nerve Tumor Registry

Frontiers in Oncology
ObjectivePeripheral nerve tumors (PNTs) are rare diseases. So far, no multicenter data on diagnostics, the efficacy of treatment, long-term outcomes, and health-related quality of life (HRQoL) exist.
Nadja Grübel, Gregor Antoniadis, Uerschels AK, Benjamin Mayer, Ralph König, Christian Rainer Wirtz, Andrej Pala, Nora F. Dengler, Maria Teresa Pedro   +8 more
doaj   +1 more source

Development of affinity-based delivery of NGF from a chondroitin sulfate biomaterial. [PDF]

, 2011
Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Chondroitin sulfate is upregulated at injury, thus methods to promote neurite extension through chondroitin sulfate-rich matrices and
Butterfield, Karen Chao, Conovaloff, Aaron W, Panitch, Alyssa   +2 more
core   +1 more source

Thrombin regulates the ability of Schwann cells to support neuritogenesis and to maintain the integrity of the nodes of Ranvier [PDF]

, 2020
Schwann cells (SC) are characterized by a remarkable plasticity that enables them to promptly respond to nerve injury promoting axonal regeneration. In peripheral nerves after damage SC convert to a repair-promoting phenotype activating a sequence of ...
Ciraci, Viviana, De Franchis, Valerio, Fabrizi, Cinzia, Familiari, Giuseppe, Familiari, Pietro, Fumagalli, Lorenzo, Leone, Stefano, Matassa, Roberto, Pompili, Elena, Tata, Ada Maria   +9 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intraoperative 3D Navigation‐Guided Resection of Enlarged Transverse Process for Treating Bertolotti Syndrome Unresponsive to Noninvasive Treatments: Case Report

Clinical Case Reports
Bertolotti syndrome is a lumbosacral anomaly that induces persistent lumbar pain. This case describes 3D navigation‐guided resection of an enlarged transverse process.
Jakub Jankowski, Marcin Glin, Natalia Maślanek, Wiktoria Chyra, Agnieszka Pawełczyk, Maciej Radek   +5 more
doaj   +1 more source

Biceps lasso loop and self-locking tenodesis alongside repair of rotator cuff tears: randomised controlled trial study protocol (BLAST 1)

BMJ Open
Introduction Pathology of the long head of the biceps tendon (LHBT) frequently accompanies rotator cuff tears, with tenotomy and tenodesis often being used to address this pathology. While meta-analyses report comparable functional outcomes between these
Michel P J van den Bekerom, Thibault Lafosse, Geert Alexander Buijze, Igor J Shirinskiy, Dries Boulidam, Arno A Macken   +5 more
doaj   +1 more source

Development and training of a machine learning algorithm to identify patients at risk for recurrence following an arthroscopic Bankart repair (CLEARER): protocol for a retrospective, multicentre, cohort study

BMJ Open, 2022
Introduction Shoulder instability is a common injury, with a reported incidence of 23.9 per 100 000 person-years. There is still an ongoing debate on the most effective treatment strategy.
, S Nakagawa, L Rossi, Michel P J van den Bekerom, H Nakamura, A Lin, M Gotoh, Y V Kleinlugtenbelt, M Loppini, Job N Doornberg, P MacDonald, Laurent Lafosse, A Stone, Sanne H van Spanning, Lukas P E Verweij, Laurens J H Allaart, Laurent A M Hendrickx, George S Athwal, Thibault Lafosse, Geert Alexander Buijze, T Flinkillä, B R Waterman, B Owens, I Pasqualini, M Scheibel, M Minkus, J S Shaha, M A Ruiz Ibán, R T Li, J M Woodmass, J Phadnis, C Hatrick, T P van Iersel   +32 more
doaj   +1 more source

Rapid Isolation of Dorsal Root Ganglion Macrophages. [PDF]

, 2019
There are growing interests to study the molecular and cellular interactions among immune cells and sensory neurons in the dorsal root ganglia after peripheral nerve injury.
Guan, Zhonghui, Leff, Jacqueline, Yu, Xiaobing   +2 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source