Results 81 to 90 of about 1,668,775 (361)

Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function

Frontiers in Cell and Developmental Biology, 2020
Alpha-Synuclein (αSyn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson’s disease.
Marina I. Oliveira da Silva, Marina I. Oliveira da Silva, Márcia A. Liz   +2 more
doaj   +1 more source

Neuropeptides Involved in Facial Nerve Regeneration

Biomedicines, 2021
Neuropeptides and neurotransmitters act as intermediaries to transmit impulses from one neuron to another via a synapse. These neuropeptides are also related to nerve degeneration and regeneration during nerve damage.
Inhyeok Kim, Yonjae Kim, Daewoong Kang, Junyang Jung, Sungsoo Kim, Hwasung Rim, Sanghoon Kim, Seung-Geun Yeo   +7 more
doaj   +1 more source

Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury

Stem cell research & therapeutics, 2020
The development of new treatment strategies to improve peripheral nerve repair after injury, especially those that accelerate axonal nerve regeneration, is very important.
Jiuhong Zhao, Yali Ding, Rui He, Kui Huang, Lucinda S Liu, Chaona Jiang, Zhuozhou Liu, Yuanlan Wang, Xiaokai Yan, Fuyang Cao, Xueying Huang, Yanan Peng, Rui Ren, Yuebin He, Tian-wei Cui, Quanpeng Zhang, Xianfang Zhang, Qibing Liu, YunQing Li, Zhijian Ma, Xinan Yi   +20 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Biomaterials and Strategies for Nerve Regeneration [PDF]

, 2009
Nerve regeneration is a complex biological phenomenon. Once the nervous system is impaired, its recovery is difficult and malfunctions in other parts of the body may occur because mature neurons do not undergo cell division.
HUANG, YI-YOU, 黃義侑
core  

DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

JOR Spine, 2023
Background Ossification of the posterior longitudinal ligaments (OPLL) is common disorder characterized by heterotopic ossification of the spinal ligaments. Mechanical stimulation (MS) plays an important role in OPLL.
Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu, Zhiyu Zhou, Shaoyu Liu   +13 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Anti-Inflammatory and Synaptic Protective Effects of TNF-α Inactivation in the MDX Mouse Model

Current Issues in Molecular Biology
Background: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by the absence of functional dystrophin, leading to progressive muscle degeneration, inflammation, and alterations in the central nervous system.
Anna Oller Bonani, Valquíria Matheus, Ana Laura Midori Rossi Tomiyama, Alexandre Leite Rodrigues de Oliveira   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effectiveness of 3-dimensional analysis of ambulatory motor function during the process of artificial nerve regeneration in dogs [PDF]

, 2004
We longitudinally assessed mainly ambulatory motor function using beagles with nerve regeneration via a polyglycolic acid (PGA)-collagen tube. Histological and electrophysiological assessment are important means of assessment of the regeneration process,
Tasato, Hiroshi, Nakamura, Tatsuo, Endo, Katsuaki, Fujikawa, Takamitsu, Fukuda, Seijun   +4 more
core   +1 more source