Results 91 to 100 of about 118,456 (317)

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Biomaterials and Strategies for Nerve Regeneration

, 2009
Nerve regeneration is a complex biological phenomenon. Once the nervous system is impaired, its recovery is difficult and malfunctions in other parts of the body may occur because mature neurons do not undergo cell division.
HUANG, YI-YOU, 黃義侑
core  

Embryonic stem cells overexpressing high molecular weight FGF2 isoform enhance recovery of pre-ganglionic spinal root lesion in combination with fibrin biopolymer mediated root repair

Stem Cell Research & Therapy
Background Spinal ventral root avulsion results in massive motoneuron degeneration with poor prognosis and high costs. In this study, we compared different isoforms of basic fibroblast growth factor 2 (FGF2), overexpressed in stably transfected Human ...
B. H. M. Lima, L. P. Cartarozzi, S. Kyrylenko, R. S. Ferreira, B. Barraviera, Alexandre L. R. Oliveira   +5 more
doaj   +1 more source

Inhibition of CD44 suppresses the formation of fibrotic scar after spinal cord injury via the JAK2/STAT3 signaling pathway

iScience
Summary: Fibrotic scar is one of the main impediments to axon regeneration following spinal cord injury (SCI). In this study, we found that CD44 was upregulated during the formation of fibrotic scar, and blocking CD44 by IM7 caused downregulation of ...
Jin Guo, Tuo Yang, Weizhong Zhang, Kaiming Yu, Xiong Xu, Weizhen Li, Lili Song, Xiaosong Gu, Rangjuan Cao, Shusen Cui   +9 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Effectiveness of 3-dimensional analysis of ambulatory motor function during the process of artificial nerve regeneration in dogs

, 2004
We longitudinally assessed mainly ambulatory motor function using beagles with nerve regeneration via a polyglycolic acid (PGA)-collagen tube. Histological and electrophysiological assessment are important means of assessment of the regeneration process,
Tasato, Hiroshi, Nakamura, Tatsuo, Endo, Katsuaki, Fujikawa, Takamitsu, Fukuda, Seijun   +4 more
core  

Cross species reproducibility of MRI radiomics features enables intervertebral disc degeneration assessment in experimental monkeys

Scientific Reports
Experimental monkeys serve as a bridge between basic research and clinical medicine. Accurately assessing the degree of intervertebral disc degeneration (IVDD) in experimental monkeys is crucial for further intervertebral disc related research in these ...
Jianmin Wang, Lei Guo, Jianfeng Li, Xiaodong Cao, Wei Du, Jiaxiang Zhou, Haizhen Li, Junhong Li, Zhengya Zhu, Tao Tang, Xianlong Li, Zhiyu Zhou, Zhiguo Liu, Yongming Xi, Manman Gao   +14 more
doaj   +1 more source

Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from an in vivo mouse model

Frontiers in Physiology
IntroductionOssification of the posterior longitudinal ligaments (OPLL) is characterized by heterotopic ossification in the posterior longitudinal ligament of spine.
Tao Tang, Tao Tang, Zhengya Zhu, Zhengya Zhu, Zhongyuan He, Zhongyuan He, Fuan Wang, Lin Chen, Jianfeng Li, Hongkun Chen, Jiaxiang Zhou, Jianmin Wang, Shaoyu Liu, Yunfeng Yao, Xizhe Liu, Zhiyu Zhou   +15 more
doaj   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source