Results 111 to 120 of about 829,895 (308)

Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes

JOR Spine
Objectives The main objective of this study was to establish a mouse model of spinal ligament ossification to simulate the chronic spinal cord compression observed in patients with ossification of the posterior longitudinal ligament (OPLL).
Zhongyuan He, Tao Tang, Zhengya Zhu, Fuan Wang, Jianfeng Li, Fu Zhang, Nguyen Tran Canh Tung, Shaoyu Liu, Xizhe Liu, Zhiyu Zhou   +9 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Overlapping Mechanisms of Peripheral Nerve Regeneration and Angiogenesis Following Sciatic Nerve Transection

Frontiers in Cellular Neuroscience, 2017
Peripheral nervous system owns the ability of self-regeneration, mainly in its regenerative microenvironment including vascular network reconstruction. More recently, more attentions have been given to the close relationship between tissue regeneration ...
Hongkui Wang, Hui Zhu, Hui Zhu, Qi Guo, Tianmei Qian, Ping Zhang, Shiying Li, Chengbin Xue, Chengbin Xue, Xiaosong Gu, Xiaosong Gu   +10 more
doaj   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells [PDF]

, 2012
Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer, Hellström Mats, Alan R Harvey, Jennifer Rodger, Mats Hellström, Hellström, M., Robertson, D., Harvey, A.R., Donald Robertson, Drummond Eleanor S., Harvey Alan R., Eleanor S Drummond, Rodger, J., Drummond, E.S., Robertson Donald   +14 more
core   +2 more sources

Negative Pressure Neurogenesis: A Novel Approach to Accelerate Nerve Regeneration after Complete Peripheral Nerve Transection

, 2021
Background: Various modalities to facilitate nerve regeneration have been described in the literature with limited success. We hypothesized that negative pressure applied to a sectioned peripheral nerve would enhance nerve regeneration by promoting ...
Ullah Sahar, MS, James St John, Sanchez-Herrero, A, Felicity Lawrence, Barton, M, Matthew Barton, Lawrence, F, Alvaro Sanchez-Herrero, Randy Bindra, Mettyas, T, Muhammad Sana Ullah Sahar, St John, J, Bindra, R, Tamer Mettyas, Shah, M, Megha Shah   +15 more
core   +1 more source

Urokinase plasminogen receptor and the fibrinolytic complex play a role in nerve repair after nerve crush in mice, and in human neuropathies.

PLoS ONE, 2012
Remodeling of extracellular matrix (ECM) is a critical step in peripheral nerve regeneration. In fact, in human neuropathies, endoneurial ECM enriched in fibrin and vitronectin associates with poor regeneration and worse clinical prognosis.
Cristina Rivellini, Giorgia Dina, Emanuela Porrello, Federica Cerri, Marina Scarlato, Teuta Domi, Daniela Ungaro, Ubaldo Del Carro, Alessandra Bolino, Angelo Quattrini, Giancarlo Comi, Stefano C Previtali   +11 more
doaj   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source

Peripheral nerve regeneration with conduits: use of vein tubes

, 2015
Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process.
Rodrigo Guerra Sabongi, Sabongi, Rodrigo Guerra [UNIFESP], Fernandes, Marcela [UNIFESP], Santos, João Baptista Gomes dos [UNIFESP], Marcela Fernandes, João Baptista Gomes dos Santos   +5 more
core   +1 more source