Results 101 to 110 of about 784,496 (306)

Negative Pressure Neurogenesis: A Novel Approach to Accelerate Nerve Regeneration after Complete Peripheral Nerve Transection

, 2021
Background: Various modalities to facilitate nerve regeneration have been described in the literature with limited success. We hypothesized that negative pressure applied to a sectioned peripheral nerve would enhance nerve regeneration by promoting ...
Ullah Sahar, MS, James St John, Sanchez-Herrero, A, Felicity Lawrence, Barton, M, Matthew Barton, Lawrence, F, Alvaro Sanchez-Herrero, Randy Bindra, Mettyas, T, Muhammad Sana Ullah Sahar, St John, J, Bindra, R, Tamer Mettyas, Shah, M, Megha Shah   +15 more
core   +1 more source

Hydrogels Augmented With Artificial Sweeteners can Inhibit Multidrug‐Resistant Acinetobacter baumannii Growth and Biofilm Formation While Demonstrating Safety in Pre‐Clinical Pilot Human Trials

Advanced Healthcare Materials, EarlyView.
Using PVA–borax hydrogels as carriers for off‐the‐shelf artificial sweeteners to fight multidrug‐resistant A. baumannii. These soft, biocompatible hydrogels rapidly reduce bacterial viability within multidrug‐resistant A. baumannii biofilms by more than 99% within one hour and sustain antimicrobial activity over time, while demonstrating safety in both
Jie Han, Mohamed Soliman, Bin Zhang, Dominika Krawiel, Ronan R. McCarthy   +4 more
wiley   +1 more source

Overlapping Mechanisms of Peripheral Nerve Regeneration and Angiogenesis Following Sciatic Nerve Transection

Frontiers in Cellular Neuroscience, 2017
Peripheral nervous system owns the ability of self-regeneration, mainly in its regenerative microenvironment including vascular network reconstruction. More recently, more attentions have been given to the close relationship between tissue regeneration ...
Hongkui Wang, Hui Zhu, Hui Zhu, Qi Guo, Tianmei Qian, Ping Zhang, Shiying Li, Chengbin Xue, Chengbin Xue, Xiaosong Gu, Xiaosong Gu   +10 more
doaj   +1 more source

Water‐Soluble, Enzyme‐Degradable, and Hydrolyzable STAR Particles for Enhanced Drug Delivery to Skin

Advanced Healthcare Materials, EarlyView.
Biodegradable polymer STAR particles fabricated from water‐soluble, enzyme‐degradable, and hydrolyzable materials significantly enhance intradermal drug delivery. By replacing conventional non‐biodegradable materials, these STAR particles address environmental and safety concerns while expanding the potential of skin‐based drug delivery technologies ...
Aydin Sadeqi, Gülçin Arslan Azizoğlu, Mark R. Prausnitz   +2 more
wiley   +1 more source

Urokinase plasminogen receptor and the fibrinolytic complex play a role in nerve repair after nerve crush in mice, and in human neuropathies.

PLoS ONE, 2012
Remodeling of extracellular matrix (ECM) is a critical step in peripheral nerve regeneration. In fact, in human neuropathies, endoneurial ECM enriched in fibrin and vitronectin associates with poor regeneration and worse clinical prognosis.
Cristina Rivellini, Giorgia Dina, Emanuela Porrello, Federica Cerri, Marina Scarlato, Teuta Domi, Daniela Ungaro, Ubaldo Del Carro, Alessandra Bolino, Angelo Quattrini, Giancarlo Comi, Stefano C Previtali   +11 more
doaj   +1 more source

PEOT/PBT Guides Enhance Nerve Regeneration in Long Gap Defects [PDF]

, 2017
Development of new nerve guides is required for replacing autologous nerve grafts for the repair of long gap defects after nerve injury. A nerve guide comprised only of electrospun fibers able to bridge a critical (15 mm) nerve gap in a rat animal model ...
Moroni, Lorenzo, Moroni, Lorenzo; id_orcid, Paul Wieringa, Santos, Daniel, Jaume Del Valle, Lorenzo Moroni, Xavier Navarro, Navarro, Xavier, Del Valle, Jaume, Daniel Santos, Wieringa, Paul; id_orcid, Wieringa, Paul   +11 more
core   +2 more sources

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons [PDF]

, 2014
This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon, Dotti, Carlos G, Andrews, Melissa R., Andrews, Melissa Renee, Kappagantula, Sunil, Abad-Rodriguez, Jose', Abad-Rodriguez, José, Fawcett, James W   +7 more
core   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells [PDF]

, 2012
Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer, Hellström Mats, Alan R Harvey, Jennifer Rodger, Mats Hellström, Hellström, M., Robertson, D., Harvey, A.R., Donald Robertson, Drummond Eleanor S., Harvey Alan R., Eleanor S Drummond, Rodger, J., Drummond, E.S., Robertson Donald   +14 more
core   +2 more sources