Results 101 to 110 of about 1,668,775 (361)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Advances in adhesion interfaces of peripheral nerve repair materials: mechanism, classification, evaluation method, and functionalization

Frontiers in Cell and Developmental Biology
Peripheral nerve injury is a prevalent clinical disease, but achieving functional recovery remains a significant research challenge. In recent years, the therapeutic efficacy of nerve repair materials has garnered widespread attention from researchers ...
Qi Meng, Qi Meng, Qi Meng, Qi Meng, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Yichong Zhang, Yichong Zhang, Yichong Zhang, Yichong Zhang, Haoran Jiang, Haoran Jiang, Haoran Jiang, Haoran Jiang, Yang Qu, Yang Qu, Yang Qu, Yang Qu, Ci Li, Chenyujun Hu, Chenyujun Hu, Chenyujun Hu, Chenyujun Hu, Zhihao Lin, Zhihao Lin, Zhihao Lin, Zhihao Lin, Bohan Xing, Bohan Xing, Bohan Xing, Bohan Xing, Fengxue Zhu, Peixun Zhang, Peixun Zhang, Peixun Zhang, Peixun Zhang, Peixun Zhang   +38 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The role of growth associated transcription factors c-Jun and ATMIN in neuronal regeneration and repair [PDF]

, 2010
Subsequent to neuronal injury, increased levels of protein synthesis accompany associated rises in transcription factor expression. Two transcription factors involved in the cellular stress response are c-Jun and ATMIN. Neuron-specific deletion of c-Jun
Ruff, C.A.D.B.
core  

A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. [PDF]

PLoS ONE, 2017
Adult vertebrates have retained the ability to regenerate peripheral nerves after injury, although regeneration is frequently incomplete, often leading to functional impairments.
Juliane Bremer, Julianne Skinner, Michael Granato   +2 more
doaj   +1 more source

Application of stem cells in peripheral nerve regeneration

Burns & Trauma, 2020
Traumatic peripheral nerve injury is a worldwide clinical issue with high morbidity. The severity of peripheral nerve injury can be classified as neurapraxia, axonotmesis or neurotmesis, according to Seddon’s classification, or five different degrees ...
Sheng Yi, Yu Zhang, Xiaokun Gu, Li Huang, Kairong Zhang, T. Qian, Xiaosong Gu   +6 more
semanticscholar   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Biodegradable hydrogels as scaffolds for nerve regeneration [PDF]

, 2010
Biodegradable hydrogels as scaffolds for nerve regeneration Valerio Magnaghi 1, Elisabetta Ranucci 2, Fabio Fenili 2, Patrizia Procacci 3, Giorgio Pivato 4, Paolo Cortese 4 and Paolo Ferruti 2 1 Department of Endocrinology, Physiopathology ...
V. Magnaghi, G. Pivato, F. Fenili, P. Procacci, P. Ferruti, E. Ranucci, P. Cortese   +6 more
core  

Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration [PDF]

, 2015
The only types of polyhydroxyalkanoates (PHAs) that have been explored for use in nerve regeneration are poly(3-hydroxybutyrate), P(3HB), and poly(3- hydroxybutyrate-co-3-hydroxyhexanoate) (P(3HB-co-3HHx)). However, nerve regeneration induced by these
Lizarraga Valderrama, L., Nigmatullin, R., Nigmatullin, R, Lizarraga-Valderrama, L.R., Claeyssens, F., Claeyssens, F, Knowles, J.C., Roy, I., Knowles, JC, Lizarraga-Valderrama, LR, Taylor, C, Roy, I, Taylor, C., Haycock, JW, Haycock, J.W.   +14 more
core   +1 more source