Results 61 to 70 of about 511,305 (158)

DataSheet1_Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion.docx

, 2022
Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2 ...
Nan Pang (5181971), Juan Xiong (547132), Fei Yin (179978), Shimeng Chen (6579029), Jing Peng (102796), Wen Zhang (7555), Li Yang (6520), Fanghua Ye (7024367), Miriam Kessi (5093426)   +8 more
core   +1 more source

Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity

eLife, 2015
Precise regulation of the dendritic spine actin cytoskeleton is critical for neurodevelopment and neuronal plasticity, but how neurons spatially control actin dynamics is not well defined.
Joju George, Cary Soares, Audrey Montersino, Jean-Claude Beique, Gareth M Thomas   +4 more
doaj   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Sylke Müller, Aparicio, I., Eva-Maria Patzewitz, Perner Jan, Isabela Aparicio, Patzewitz, E.-M., Llinas, M., Storm, J., Llinas Manuel, Engel Paul C, Olszewski Kellen, Janet Storm, Perner, J., Storm Janet, Paul C Engel, Kellen Olszewski, Engel, P.C., Manuel Llinas, Olszewski, K., Muller, S., Müller Sylke, Aparicio Isabela, Patzewitz Eva-Maria, Jan Perner, Perner, Jan, Storm, Janet, Aparicio, Isabela, Patzewitz, Eva-Maria, Olszewski, Kellen, Engel, Paul C, Llinas, Manuel, Muller, Sylke   +31 more
core   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
Attwell, D., Koodziejczyk, Karolina, Kolodziejczyk, K., Wade, A., Kradttir, Ragnhildur, Wade, Anna, Karadottir, R., Hamilton, Nicola B.; id_orcid, Attwell, David, Hamilton, N. B.   +9 more
core   +1 more source

Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia

Biomolecules, 2020
Pathological homocysteine (HCY) accumulation in the human plasma, known as hyperhomocysteinemia, exacerbates neurodegenerative diseases because, in the brain, this amino acid acts as a persistent N-methyl-d-aspartate receptor agonist.
Maria A. Ivanova, Arina D. Kokorina, Polina D. Timofeeva, Tatiana V. Karelina, Polina A. Abushik, Julia D. Stepanenko, Dmitry A. Sibarov, Sergei M. Antonov   +7 more
doaj   +1 more source

Exploration of the glutamate-mediated retinal excitotoxic damage: a rat model of retinal neurodegeneration [PDF]

International Journal of Ophthalmology, 2018
AIM: To explore the more suitable concentration of glutamate or N-methyl-D-aspartic acid (NMDA) for intravitreal injection to establish a rat model of retinal neurodegeneration.
Ling Gao, Qi-Jun Zheng, Li-Qian-Yu Ai, Kai-Jian Chen, Yuan-Guo Zhou, Jian Ye, Wei Liu   +6 more
doaj   +1 more source

Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons [PDF]

, 2006
Basal forebrain (BF) neurons provide the principal cholinergic drive to the hippocampus and cortex. Their degeneration is associated with the cognitive defects of Alzheimer's disease. Immunohistochemical studies suggest that some of these neurons contain
Allen, TGJ, Abogadie, FC, Brown, DA
core  

Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway [PDF]

, 2008
The Breuer-Hering inflation reflex is initiated by activation of the slowly adapting pulmonary stretch receptor afferents (SARs), which monosynaptically activate second-order relay neurones in the dorsal medullary nucleus of the solitary tract (NTS ...
Enrique Llaudet, Gourine, Alexander V., Robert Huckstepp, Faming Tian, K. Michael Spyer, Korsak, Alla, Dale, Nicholas, Huckstepp, Robert T. R., Tian, Faming, Alexander V. Gourine, Spyer, K. Michael, Llaudet, Enrique, Alla Korsak, Nicholas Dale   +13 more
core   +1 more source

An Excitatory/Inhibitory Switch From Asymmetric Sensory Neurons Defines Postsynaptic Tuning for a Rapid Response to NaCl in Caenorhabditis elegans

Frontiers in Molecular Neuroscience, 2019
The neural networks that regulate animal behaviors are encoded in terms of neuronal excitation and inhibition at the synapse. However, how the temporal activity of neural circuits is dynamically and precisely characterized by each signaling interaction ...
Masahiro Kuramochi, Motomichi Doi
doaj   +1 more source

Counting the Number of Glutamate Molecules in Single Synaptic Vesicles [PDF]

, 2019
Analytical tools for direct quantitative measurements of glutamate, the principal excitatory neurotransmitter in brain, are lacking. Here, we introduce a new enzyme-based amperometric sensor technique for direct counting of the number of glutamate ...
Hoda, fathali, Jacqueline, Keighron, karolina, skibicka, Ann-Sofie, Cans, Yuanmo, Wang, devesh, mishra, Thomas, Olsson   +6 more
core   +1 more source