Results 81 to 90 of about 662,038 (354)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
Attwell, D., Koodziejczyk, Karolina, Kolodziejczyk, K., Wade, A., Kradttir, Ragnhildur, Wade, Anna, Karadottir, R., Hamilton, Nicola B.; id_orcid, Attwell, David, Hamilton, N. B.   +9 more
core   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Early predictors and prevention for post-stroke epilepsy: changes in neurotransmitter levels

Translational Neuroscience, 2016
Background: The purpose of this study was to identify predictors and preventative treatments for post-stroke epilepsy (PSE). Methodology: Eighty-four patients who had suffered a cerebrovascular insult (within 72 hours) were recruited and divided into two
Xie Wen-Jing, Dong Ming, Liu Qun, Meng Hong-Mei   +3 more
doaj   +1 more source

The Effects of Enriched Rehabilitation on Cognitive Function and Serum Glutamate Levels Post-stroke

Frontiers in Neurology, 2022
AimThis study aimed to explore the effect of enriched rehabilitation (ER) on cognitive function and serum glutamate levels in patients with stroke.MethodsForty patients diagnosed with post-stroke cognitive impairment (PSCI), according to the inclusion ...
Xin Wang, Yuan Peng, Hongyu Zhou, Wanchun Du, Junya Wang, JiaJin Wang, Tong Wu, Xiaojia Tang, Yichen Lv, Jianwei Gong   +9 more
doaj   +1 more source

Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR

Nature Methods, 2018
Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with high spatial and temporal resolution. We report variants of intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) that are functionally brighter ...
J. Marvin, B. Scholl, Daniel E. Wilson, Kaspar Podgorski, Abbas Kazemipour, J. A. Müller, S. Schoch, F. J. U. Quiroz, N. Rebola, Huan Bao, J. P. Little, A. N. Tkachuk, Edward Cai, A. Hantman, S. Wang, Victor J. DePiero, B. Borghuis, E. Chapman, D. Dietrich, D. DiGregorio, D. Fitzpatrick, L. Looger   +21 more
semanticscholar   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Regulation of osmoadaptation in the moderate halophile Halobacillus halophilus : chloride, glutamate and switching osmolyte strategies [PDF]

, 2008
The moderate halophile Halobacillus halophilus is the paradigm for chloride dependent growth in prokaryotes. Recent experiments shed light on the molecular basis of the chloride dependence that is reviewed here.
Saum, Stephan H., Müller, Volker
core   +1 more source

Cestode larvae excite host neuronal circuits via glutamatergic signalling

eLife
Neurocysticercosis (NCC) is caused by infection of the brain by larvae of the parasitic cestode Taenia solium. It is the most prevalent parasitic infection of the central nervous system and one of the leading causes of adult-acquired epilepsy worldwide ...
Anja de Lange, Hayley Tomes, Joshua S Selfe, Ulrich Fabien Prodjinotho, Matthijs B Verhoog, Siddhartha Mahanty, Katherine Ann Smith, William Horsnell, Chummy Sikasunge, Clarissa Prazeres da Costa, Joseph V Raimondo   +10 more
doaj   +1 more source