Results 71 to 80 of about 502,486 (298)

Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST? [PDF]

, 2005
PURPOSE: We previously demonstrated that exogenous glial cell line-derived neurotrophic factor (GDNF) induces histological and functional protection of photoreceptors in the retinal degeneration (rd1) mouse model.
Neveux, N, Leveillard, T, Sahel, JA, Simonutti, M, Delyfer, MN   +4 more
core  

Neuronal vs glial glutamate uptake: Resolving the conundrum [PDF]

, 2016
Neither normal brain function nor the pathological processes involved in neurological diseases can be adequately understood without knowledge of the release, uptake and metabolism of glutamate.

core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Glutamate signaling in bone

Frontiers in Endocrinology, 2012
Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt to its environment, however characterization of the signaling events linking load to bone formation is incomplete. A screen for genes associated with mechanical load-induced bone formation identified the glutamate transporter GLAST, implicating the ...
Brakspear, Karen S., Mason, Deborah J.
openaire   +3 more sources

Cytophilic Antibodies to Plasmodium Falciparum Glutamate Rich Protein are Associated with Malaria Protection in an Area of Holoendemic Transmission. [PDF]

, 2005
Several studies conducted in areas of medium or low malaria transmission intensity have found associations between malaria immunity and plasma antibody levels to glutamate rich protein (GLURP).
Thor G Theander, Theisen, Michael, Martha M Lemnge, Mmbando, Bruno P, Mmbando Bruno P, Kitua, Andrew Y, Lemnge Martha M, Lemnge, Martha M, Theander, Thor G, Andrew Y Kitua, Vestergaard Lasse S, Lasse S Vestergaard, Alifrangis Michael, Theander Thor G, Bruno P Mmbando, Theisen Michael, Vestergaard, Lasse S, Kitua Andrew Y, Lusingu, John P A, Lusingu John PA, Michael Alifrangis, Alifrangis, Michael, Michael Theisen, John PA Lusingu   +23 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Targeting glutamate metabolism in chronic lung diseases

Clinical and Translational Discovery
Amino acids are necessary for all life forms, which play various roles. Disorder of amino acid metabolism is now considered an important driving mechanism in diverse pulmonary conditions, particularly chronic lung diseases like chronic obstructive ...
Zhihou Guo, Furong Yan
doaj   +1 more source

Alterations of Astrocytes in the Context of Schizophrenic Dementia

Frontiers in Pharmacology, 2020
The levels of the astrocyte markers (GFAP, S100B) were increased unevenly in patients with schizophrenia. Reactive astrogliosis was found in approximately 70% of patients with schizophrenia.
Vadim V. Tarasov, Andrey A. Svistunov, Vladimir N. Chubarev, Susanna S. Sologova, Polina Mukhortova, Dmitrii Levushkin, Siva G. Somasundaram, Cecil E. Kirkland, Sergey O. Bachurin, Gjumrakch Aliev, Gjumrakch Aliev, Gjumrakch Aliev, Gjumrakch Aliev   +12 more
doaj   +1 more source

Glutamate-activated currents of CrGluCl-B cRNA-injected Xenopus oocytes.

, 2023
A. Current traces obtained at the indicated membrane potentials during bath application of glutamate at concentrations from 10 μM to 3 mM, or 3 μM ivermectin during the times shown in the boxes. B.
L. Pablo Cid (14790836), Felipe Tribiños (14790827), Francisco V. Sepúlveda (14790833), Isabel Cornejo (634494), Patricio Cuevas (14790830)   +4 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source