Results 41 to 50 of about 1,092,184 (348)

The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

eLife, 2019
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones, Keri L Hildick, Ashley J Evans, Yasuko Nakamura, Kevin A Wilkinson, Jeremy M Henley   +5 more
doaj   +1 more source

Network self-organization explains the statistics and dynamics of synaptic connection strengths in cortex [PDF]

, 2013
The information processing abilities of neural circuits arise from their synaptic connection patterns. Understanding the laws governing these connectivity patterns is essential for understanding brain function.
Jochen Triesch (106561), Dimitrakakis, Christos, Pengsheng Zheng, Triesch, J., Jochen Triesch, Christos Dimitrakakis (106559), Zheng, Pengsheng, Zheng, P.,, Zheng, P., Triesch, J.,, Triesch, Jochen, Dimitrakakis, Christos,, Christos Dimitrakakis, Pengsheng Zheng (106555)   +13 more
core   +1 more source

Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

Neuron, 2017
Marco Capogna, Sadegh Nabavi, Marco Bocchio   +2 more
exaly   +2 more sources

Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation

STAR Protocols, 2021
Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin beads
Jithin D. Nair, Jeremy M. Henley, Kevin A. Wilkinson   +2 more
doaj   +1 more source

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Nature Medicine, 2019
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco, R. Frozza, Guilherme B. de Freitas, Hong Zhang, G. C. Kincheski, Felipe C. Ribeiro, R. A. Gonçalves, J. Clarke, Danielle Beckman, Agnieszka Staniszewski, H. Berman, L. A. Guerra, Letícia Forny-Germano, Shelby E. Meier, D. Wilcock, J. D. de Souza, S. Alves-Leon, V. Prado, M. Prado, J. Abisambra, F. Tovar-Moll, P. Mattos, O. Arancio, S. Ferreira, F. D. De Felice   +24 more
semanticscholar   +1 more source

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

bioRxiv, 2020
Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic plateau potentials has been reported to underlie place field formation in ...
Aaron D. Milstein, Yiding Li, Katie C. Bittner, Christine Grienberger, I. Soltesz, J. Magee, S. Romani   +6 more
semanticscholar   +1 more source

MAGUKs, Synaptic Development, and Synaptic Plasticity [PDF]

The Neuroscientist, 2011
MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication.
Chan-Ying, Zheng, Gail K, Seabold, Martin, Horak, Ronald S, Petralia   +3 more
openaire   +2 more sources

The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis

Frontiers in Endocrinology, 2021
BackgroundSchizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease’s ...
Jianbo Yu, Xufeng Liao, Yanzi Zhong, Yanzi Zhong, Yongqiang Wu, Xinsheng Lai, Xinsheng Lai, Huifeng Jiao, Min Yan, Yu Zhang, Chaolin Ma, Chaolin Ma, Shunqi Wang, Shunqi Wang   +13 more
doaj   +1 more source

Pre-synaptic terminal dynamics in the hippocampus [PDF]

, 2003
This thesis work dealt with the study of synaptic plasticity in the adult brain. This is an area of intensive investigation because instability of synapses is believed to underlie cognitive processes like learning and memory in the CNS, and adaptation ...
De Paola, Vincenzo
core   +1 more source

Learning with delayed synaptic plasticity [PDF]

Proceedings of the Genetic and Evolutionary Computation Conference, 2019
The plasticity property of biological neural networks allows them to perform learning and optimize their behavior by changing their configuration. Inspired by biology, plasticity can be modeled in artificial neural networks by using Hebbian learning rules, i.e.
Anil Yaman, Giovanni Iacca, Decebal Constantin Mocanu, George H. L. Fletcher, Mykola Pechenizkiy   +4 more
openaire   +3 more sources