Results 31 to 40 of about 1,092,184 (348)

Caspases in synaptic plasticity [PDF]

Molecular Brain, 2012
Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic plasticity, dendritic development, learning and memory. In this article, we review the studies on the non-
Li Zheng, Sheng Morgan
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Novelty producing synaptic plasticity [PDF]

Proceedings of the 2020 Genetic and Evolutionary Computation Conference Companion, 2020
A learning process with the plasticity property often requires reinforcement signals to guide the process. However, in some tasks (e.g. maze-navigation), it is very difficult (or impossible) to measure the performance of an agent (i.e. a fitness value) to provide reinforcements since the position of the goal is not known.
Anil Yaman, Giovanni Iacca, Decebal Constantin Mocanu, George Fletcher 0001, Mykola Pechenizkiy   +4 more
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Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Frontiers in Synaptic Neuroscience, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Luke Yuri Prince, Travis J Bacon, Cezar M. Tigaret, Jack R Mellor   +3 more
doaj   +1 more source

Metformin Increases Sarcolemma Integrity and Ameliorates Neuromuscular Deficits in a Murine Model of Duchenne Muscular Dystrophy

Frontiers in Physiology, 2021
Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disease characterized by progressive muscle weakness and wasting. Stimulation of AMP-activated protein kinase (AMPK) has been demonstrated to increase muscle function and protect muscle against
Xia Dong, Xia Dong, Tiankun Hui, Tiankun Hui, Jie Chen, Jie Chen, Zheng Yu, Dongyan Ren, Dongyan Ren, Suqi Zou, Suqi Zou, Shunqi Wang, Shunqi Wang, Erkang Fei, Erkang Fei, Huifeng Jiao, Xinsheng Lai, Xinsheng Lai   +17 more
doaj   +1 more source

MSK1 regulates homeostatic and experience-dependent synaptic plasticity [PDF]

, 2012
The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response ...
Frenguelli, BrunoG., Corrêa, SAL, McKenzie, Colin, Palygin, O, Palygin, Oleg, Martin, KJ, Arthur, J.S., McKelvey, Kim, Hunter, CJ, Morris, R. G. M. (Richard G. M.), Morris, R.G., Morris, RGM, McKenzie, C, Hunter, Christopher J., Wauters, Sandrine C., Pankratov, Yuriy, Hunter, C.J., Wauters, S.C., Wauters, SC, Wauters, Sandrine, Martin, K.J., Arthur, J.Simon C.; id_orcid, Palygin, O., Frenguelli, BG, Corrêa, Sonia A.L., Corrêa, Sônia A. L., Arthur, J. Simon C., Frenguelli, Bruno G., Morris, Richard G. M., Frenguelli, B.G., Pankratov, Y., Martin, Kirsty J., McKelvey, Kim M. (Kim Martin), McKenzie, C., Arthur, JSC, McKelvey, K., Pankratov, Y, McKelvey, K   +37 more
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Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits

Nature Neuroscience, 2020
Synaptic plasticity is believed to be a key physiological mechanism for learning. It is well established that it depends on pre- and postsynaptic activity.
Alexandre Payeur, Jordan Guerguiev, Friedemann Zenke, B. Richards, R. Naud   +4 more
semanticscholar   +1 more source

Structural Plasticity in Neuronal Networks [PDF]

, 2007
Neuronal networks are established during development by the formation of connections (synapses) between neurons. Once formed, these synapses undergo experience-dependent modifications throughout the lifespan of the animal (synaptic plasticity ...
Mysore, Shreesh Pranesh
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Optogenetics and synaptic plasticity [PDF]

Acta Pharmacologica Sinica, 2013
The intricate and complex interaction between different populations of neurons in the brain has imposed limits on our ability to gain detailed understanding of synaptic transmission and its integration when employing classical electrophysiological approaches. Indeed, electrical field stimulation delivered via traditional microelectrodes does not permit
Yu-feng, Xie, Michael F, Jackson, John F, Macdonald   +2 more
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Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice [PDF]

, 2010
Background Alzheimer disease (AD) is a neurodegenerative disorder for which there is no cure. We have investigated synaptic plasticity in area CA1 in a novel AD mouse model (APPPS1-21) which expresses the Swedish mutation of APP and the L166P mutation of
Holscher, Christian, Hamilton, A., Gengler, Simon   +2 more
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The epitranscriptome and synaptic plasticity

Current Opinion in Neurobiology, 2019
RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years, technological advances improving our ability to identify mRNA modifications, coupled with the discovery of proteins that add and remove these ...
Mathieu N Flamand, Kate D Meyer
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