Results 31 to 40 of about 179,365 (263)

Synaptic plasticity through activation of GluA3-containing AMPA-receptors

eLife, 2017
Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types of AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), and those that contain GluA2 and ...
Maria C Renner, Eva HH Albers, Nicolas Gutierrez-Castellanos, Niels R Reinders, Aile N van Huijstee, Hui Xiong, Tessa R Lodder, Helmut W Kessels   +7 more
doaj   +1 more source

Linking spontaneous and stimulated spine dynamics

Communications Biology, 2023
Our brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories.
Maximilian F. Eggl, Thomas E. Chater, Janko Petkovic, Yukiko Goda, Tatjana Tchumatchenko   +4 more
doaj   +1 more source

Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?

Frontiers in Cellular Neuroscience, 2021
Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango, Dalila Mango, Robert Nisticò, Robert Nisticò   +3 more
doaj   +1 more source

SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis

Scientific Reports, 2017
Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated.
Daniel L. Rocca, Kevin A. Wilkinson, Jeremy M. Henley   +2 more
doaj   +1 more source

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

Cell Reports, 2017
Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans, Sonam Gurung, Kevin A. Wilkinson, David J. Stephens, Jeremy M. Henley   +4 more
doaj   +1 more source

Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses

Nature Communications, 2020
In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez, Shuting Yin, Christian Schulze, John A. Hammer, Wolfgang Wagner, Thomas G. Oertner   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus

Cell Reports, 2016
Place cell firing patterns reactivated during hippocampal sharp-wave ripples (SWRs) in rest or sleep are thought to induce synaptic plasticity and thereby promote the consolidation of recently encoded information.
Josef H.L.P. Sadowski, Matthew W. Jones, Jack R. Mellor   +2 more
doaj   +1 more source

Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Nature Communications, 2021
In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor   +7 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source