Results 1 to 10 of about 1,654,724 (346)
eLife, 2017 The amyloid precursor protein (APP) harbors physiological roles at synapses and is central to Alzheimer’s disease (AD) pathogenesis. Evidence suggests that APP intracellular domain (AICD) could regulate synapse function, but the underlying molecular ...
Paula A Pousinha +11 more
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Astrocyte and Neuronal Plasticity in the Somatosensory System [PDF]
Neural Plasticity, 2015 Changing the whisker complement on a rodent’s snout can lead to two forms of experience-dependent plasticity (EDP) in the neurons of the barrel cortex, where whiskers are somatotopically represented. One form, termed coding plasticity, concerns changes in synaptic transmission and connectivity between neurons.
Sims, Robert +3 more
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Cell Type-specific Metabolic Labeling of Proteins with Azidonorleucine in Drosophila
Bio-Protocol, 2017 Advanced mass spectrometry technology has pushed proteomic analyses to the forefront of biological and biomedical research. Limitations of proteomic approaches now often remain with sample preparations rather than with the sensitivity of protein ...
Ines Erdmann +9 more
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LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice
PLoS ONE, 2017 Nogo receptor-1 (NgR1) and its ligands inhibit neuronal plasticity and limit functional recovery after brain damage such as ischemic stroke. We have previously shown that lateral olfactory tract usher substance (LOTUS) antagonizes NgR1-mediated signaling.
Hajime Takase +4 more
semanticscholar +1 more source
Strategies for the Identification of Bioactive Neuropeptides in Vertebrates
Frontiers in Neuroscience, 2019 Neuropeptides exert essential functions in animal physiology by controlling e.g., reproduction, development, growth, energy homeostasis, cardiovascular activity and stress response.
Auriane Corbière +10 more
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Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity.
Neurobiology of Disease, 2016 Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate adaptation to energetic needs, keeps mitochondria in good health ...
A. M. Bertholet +11 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2019 Rimonabant was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was withdrawn from market due to the notably increased rates of psychiatric side effects.
Vincenzo Micale +6 more
doaj +1 more source
The chromatin landscape of neuronal plasticity
Current Opinion in Neurobiology, 2019 Examining the links between neuronal activity, transcriptional output, and synaptic function offers unique insights into how neurons adapt to changing environments and form memories. Epigenetic markers, such as DNA methylation and histone modifications, have been implicated in the formation of not only cellular memories such as cell fate, but also ...
Margaret, Herre, Erica, Korb
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Journal of Neural Transplantation and Plasticity, 2018 The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus.
P. L. Bozzelli +4 more
semanticscholar +1 more source
Neuronal plasticity in nematode worms [PDF]
Nature, 2018 Neuronal activity induces changes in the connectivity of a neuron called DVB in adult male nematode worms. This discovery provides an opportunity to study a fundamental process in this powerful model organism. Neuronal activity induces changes in the connectivity of a neuron called DVB in adult male nematode worms.
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