Results 21 to 30 of about 1,654,724 (346)

Chromatin Regulation of Neuronal Maturation and Plasticity

Trends in Neurosciences, 2018
Neurons are dynamic cells that respond and adapt to stimuli throughout their long postmitotic lives. The structural and functional plasticity of neurons requires the regulated transcription of new gene products, and dysregulation of transcription in ...
Anne West, Liang-Fu Chen
exaly   +2 more sources

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

Frontiers in Molecular Neuroscience, 2016
In the brain, neuronal gene expression is dynamically changed in response to neuronal activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos, and Arc is rapidly and selectively upregulated in subsets of neurons in ...
Hiroyuki Okuno
exaly   +2 more sources

RNA granules in neuronal plasticity and disease.

Trends in Neurosciences, 2023
RNA granules are dynamic entities controlling the spatiotemporal distribution and translation of RNA molecules. In neurons, a variety of RNA granules exist both in the soma and in cellular processes.
K. Bauer, B. D. de Queiroz, M. Kiebler, F. Besse   +3 more
semanticscholar   +1 more source

Chronic pain–induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety

Science Advances, 2022
The comorbidity of chronic pain and mental dysfunctions such as depression and anxiety disorders has long been recognized, but the underlying mechanisms remain poorly understood.
Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, H. Nomura, Taiju Amano, M. Minami   +7 more
semanticscholar   +1 more source

Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease

Molecular Neurodegeneration, 2022
Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration.
P. Visser, L. Reus, J. Gobom, I. Jansen, E. Dicks, S. J. van der Lee, M. Tsolaki, F. Verhey, J. Popp, P. Martínez-Lage, R. Vandenberghe, A. Lleó, J. Molinuevo, S. Engelborghs, Y. Freund-Levi, L. Froelich, K. Sleegers, V. Dobričić, S. Lovestone, J. Streffer, S. Vos, Isabelle Bos, A. Smit, K. Blennow, P. Scheltens, C. Teunissen, L. Bertram, H. Zetterberg, B. Tijms   +28 more
semanticscholar   +1 more source

Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice

Translational Psychiatry, 2021
Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice.
Daniel E. Heinz, Vivian A. Schöttle, Paulina Nemcova, Florian P. Binder, Tim Ebert, Katharina Domschke, Carsten T. Wotjak   +6 more
doaj   +1 more source

Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer’s disease

Journal of Neurochemistry, 2021
Understanding the molecular signaling mechanisms underlying cognition and neuronal plasticity would provide insights into the pathogenesis of neuronal disorders characterized by cognitive syndromes such as Alzheimer disease (AD).
T. Ma
semanticscholar   +1 more source

Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress

Scientific Reports, 2021
The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions.
Dario Magaquian, Susana Delgado Ocaña, Consuelo Perez, C. Banchio   +3 more
semanticscholar   +1 more source

Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma

Pharmaceutics, 2022
Despite the numerous research studies on traumatic brain injury (TBI), many physiopathologic mechanisms remain unknown. TBI is a complex process, in which neuroinflammation and glial cells play an important role in exerting a functional immune and damage-
Ana Belen Lopez-Rodriguez, Céline Decouty-Perez, Victor Farré-Alins, Alejandra Palomino-Antolín, Paloma Narros-Fernández, Javier Egea   +5 more
doaj   +1 more source

Electroacupuncture improves neuronal plasticity through the A2AR/cAMP/PKA signaling pathway in SNL rats.

Neurochemistry International, 2021
Improvements in neuronal plasticity are considered to be conducive to recovery from neuropathic pain. Electroacupuncture (EA) is regarded as an effective rehabilitation method for neuropathic pain.
Qiaoyun Wu, Jie Chen, Jingjing Yue, Xinwang Ying, Ye Zhou, Xiaolong Chen, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Kecheng Zhou, Songhe Jiang   +10 more
semanticscholar   +1 more source