Results 11 to 20 of about 211,725 (313)
Autophagy in Neuronal Development and Plasticity [PDF]
Trends in Neurosciences, 2020 Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject of intense research in relation to neurodegenerative disease.
Angeleen Fleming, David C Rubinsztein
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Plasticity of intrinsic neuronal excitability [PDF]
Current Opinion in Neurobiology, 2019 Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons.
Debanne, Dominique +2 more
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Neuronal Plasticity: Beyond the Critical Period [PDF]
Cell, 2014 Neuronal plasticity in the brain is greatly enhanced during critical periods early in life and was long thought to be rather limited thereafter. Studies in primary sensory areas of the neocortex have revealed a substantial degree of plasticity in the mature brain, too.
Mark Hübener, Tobias Bonhoeffer
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Cathepsins in neuronal plasticity
Neural Regeneration Research, 2021 Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins, resulting in protein lysis. Cathepsins, specifically, encompass a class of at least twenty proteases with potent endopeptidase activity.
Amanda Phuong Tran, Jerry Silver
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Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice
Translational Psychiatry, 2021 Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice.
Daniel E. Heinz +6 more
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Pharmaceutics, 2022 Despite the numerous research studies on traumatic brain injury (TBI), many physiopathologic mechanisms remain unknown. TBI is a complex process, in which neuroinflammation and glial cells play an important role in exerting a functional immune and damage-
Ana Belen Lopez-Rodriguez +5 more
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The Histone Modifications of Neuronal Plasticity [PDF]
Neural Plasticity, 2021 Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dimensional structure of chromosomes and affect gene ...
Huixia Geng +3 more
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Lobe X of the Cerebellum: A Natural Neuro-Resistant Region
Anatomia, 2023 The cerebellum is an encephalic region classically known for its central role in the control of movement, although recent research has revealed its involvement in other cognitive and affective tasks. Several different pathologies are known to affect this
Carlos Hernández-Pérez +2 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Intranasal (IN) administration appears to be a suitable route for clinical use as it allows direct delivery of bioactive molecules to the central nervous system, reducing systemic exposure and sides effects.
Asma Cherait +10 more
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S‐nitrosation and neuronal plasticity [PDF]
British Journal of Pharmacology, 2014 Nitric oxide (NO) has long been recognized as a multifaceted participant in brain physiology. Despite the knowledge that was gathered over many years regarding the contribution of NO to neuronal plasticity, for example the ability of the brain to change in response to new stimuli, only in recent years have we begun to understand how NO acts on the ...
Santos, Ana Isabel +2 more
openaire +4 more sources