Results 11 to 20 of about 1,092,184 (348)
All-optical physiology resolves a synaptic basis for behavioral timescale plasticity
Cell, 2023 SUMMARY Learning has been associated with modifications of synaptic and circuit properties, but the precise changes storing information in mammals have remained largely unclear.
Linlin Z. Fan +13 more
exaly +2 more sources
The AMPA Receptor Code of Synaptic Plasticity
Neuron, 2018 Changes in the properties and post-synaptic abundance of AMPA-type glutamate receptors (AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including long-term potentiation (LTP), long-term depression (LTD), and homeostatic ...
Graham H Diering, Richard L. Huganir
exaly +2 more sources
Modulation of Autophagy by BDNF Underlies Synaptic Plasticity
Cell Metabolism, 2017 Autophagy is crucial for neuronal integrity. Loss of key autophagic components leads to progressive neurodegeneration and structural defects in pre- and postsynaptic morphologies. However, the molecular mechanisms regulating autophagy in the brain remain
Kyriaki Sidiropoulou +2 more
exaly +2 more sources
Current Biology, 1998 Animals live in an ever-changing environment to which they must continuously adapt. Adaptation in the nervous system occurs at every level, from ion channels and synapses to single neurons and whole networks. It operates in many different forms and on many time scales.
Stevens, Charles F, Sullivan, Jane
openaire +3 more sources
iScience, 2021 Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair +8 more
doaj +1 more source
Antioxidants, 2023 Depression is a prevalent, complex, and highly debilitating disease. The full comprehension of this disease is still a global challenge. Indeed, relapse, recurrency, and therapeutic resistance are serious challenges in the fight against depression ...
A. S. Correia, A. Cardoso, N. Vale
semanticscholar +1 more source
Microglia regulation of synaptic plasticity and learning and memory
Neural Regeneration Research, 2021 Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and ...
Jessica Cornell +3 more
semanticscholar +1 more source
GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors
iScience, 2023 Summary: Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely unexplored.
Jithin D. Nair +6 more
doaj +1 more source
Communications Biology, 2023 Curiosity, or novelty seeking, is a fundamental mechanism motivating animals to explore and exploit environments to improve survival, and is also positively associated with cognitive, intrapersonal and interpersonal well-being in humans.
Qiang Shan +4 more
doaj +1 more source
Synaptic plasticity and mental health: methods, challenges and opportunities
Neuropsychopharmacology, 2022 Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that allows neurons to communicate and change their connections as a function of past experiences.
L. Appelbaum +3 more
semanticscholar +1 more source