Results 21 to 30 of about 1,092,184 (348)
Journal of Medical Case Reports, 2022 Background The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable.
Andrea Giorni +5 more
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IBRO Neuroscience Reports, 2021 Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration in ...
Luis Solabre Valois +6 more
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LRP4 is required for the olfactory association task in the piriform cortex
Cell & Bioscience, 2022 Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long ...
Min Yan +12 more
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Simultaneous emulation of synaptic and intrinsic plasticity using a memristive synapse
Nature Communications, 2022 Neuromorphic computing targets the hardware embodiment of neural network, and device implementation of individual neuron and synapse has attracted considerable attention.
S. Sung +4 more
semanticscholar +1 more source
Control of synaptic plasticity in deep cortical networks
Nature Reviews Neuroscience, 2018 Pieter R. Roelfsema, Anthony Holtmaat
exaly +2 more sources
Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome
Frontiers in Molecular Neuroscience, 2023 Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins ...
Magdalena Chojnacka +7 more
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Subcellular RNA-seq for the Analysis of the Dendritic and Somatic Transcriptomes of Single Neurons
Bio-Protocol, 2022 In neurons, local translation in dendritic and axonal compartments allows for the fast and on-demand modification of the local proteome. As the last few years have witnessed dramatic advancements in our appreciation of the brain’s neuronal diversity, it ...
Julio Perez, Erin Schuman
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Imaging synaptic plasticity [PDF]
Molecular Brain, 2011 Over the past decade, the use and development of optical imaging techniques has advanced our understanding of synaptic plasticity by offering the spatial and temporal resolution necessary to examine long-term changes at individual synapses. Here, we review the use of these techniques in recent studies of synaptic plasticity and, in particular, long ...
Padamsey, Z, Emptage, N
openaire +4 more sources
Biology, 2020 Metformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found to reduce depressive symptoms in patients with comorbid depression and other diseases.
Jiang Chen +6 more
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Microglia regulate synaptic development and plasticity
Developmental Neurobiology, 2021 Synapses are fundamental structures of neural circuits that transmit information between neurons. Thus, the process of neural circuit formation via proper synaptic connections shapes the basis of brain functions and animal behavior. Synapses continuously
Megumi Andoh, Ryuta Koyama
semanticscholar +1 more source