Results 21 to 30 of about 316,392 (297)

Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation

STAR Protocols, 2021
Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin beads
Jithin D. Nair, Jeremy M. Henley, Kevin A. Wilkinson   +2 more
doaj   +1 more source

Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo. [PDF]

, 2015
The spatiotemporal pattern of synaptic inputs to the dendritic tree is crucial for synaptic integration and plasticity. However, it is not known if input patterns driven by sensory stimuli are structured or random.
Häusser, M, Wilms, CD
core   +1 more source

Interactions between short-term and long-term plasticity: shooting for a moving target [PDF]

, 2011
Far from being static transmission units, synapses are highly dynamical elements that change over multiple time scales depending on the history of the neural activity of both the pre- and postsynaptic neuron.
Jean-Pascal Pfister, Má
core   +2 more sources

The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis

Frontiers in Endocrinology, 2021
BackgroundSchizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease’s ...
Jianbo Yu, Xufeng Liao, Yanzi Zhong, Yanzi Zhong, Yongqiang Wu, Xinsheng Lai, Xinsheng Lai, Huifeng Jiao, Min Yan, Yu Zhang, Chaolin Ma, Chaolin Ma, Shunqi Wang, Shunqi Wang   +13 more
doaj   +1 more source

The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]

, 2017
One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A., Ali, Nilufar, Amini, Elham, Blumrich, Eva Maria, Datusalia, Ashok K., Fontanet, Paula, García Romero, Ezra Michelet, Ghosh, Shampa, Golpich, Mojtaba, Hegemann, Regina U., Jain, Vishal, Jamwal, Sumit, Joshi, Pooja, Kushwah, Neetu, Lepeta, Katarzyna, Loke, Hannah, Lourenco, Mychael V., Nawrotek, Katarzyna, Paid, Ramesh K., Pastor, Verónica, Piermartiri, Tetsade, Rotermund, Carola, Saini, Vedangana, Salamian, Ahmad, Schaefer, Natascha, Shahidzadeh, Sheila M., Sharma, Mahima, Sharma, Sorabh, Sinha, Jitendra K., Suárez Pozos, Edna, Turner, Anthony J., Vafadari, Benham, Wilson, Yvette   +32 more
core   +2 more sources

Tuning a binary ferromagnet into a multi-state synapse with spin-orbit torque induced plasticity [PDF]

, 2016
Inspired by ion-dominated synaptic plasticity in human brain, artificial synapses for neuromorphic computing adopt charge-related quantities as their weights.
Cao, Yi, Rushforth, Andrew, Sheng, Yu, Zheng, Houzhi, Wang, Kaiyou   +4 more
core   +4 more sources

Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus

Cell & Bioscience, 2019
Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu, Dong Lin, Yanzi Zhong, Bin Luo, Shengsheng Liu, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +8 more
doaj   +1 more source

Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity

Nature Communications, 2016
During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret, Valeria Olivo, Josef H.L.P. Sadowski, Michael C. Ashby, Jack R. Mellor   +4 more
doaj   +1 more source

An integrated, temporal study of the behavioural, electrophysiological and neuropathological consequences of murine prion disease

Neurobiology of Disease, 2006
We have conducted an integrated study of ME7 prion disease by examining the electrophysiological and neuropathological features of hippocampal slices from behaviourally characterised C57Bl/6J mice 12, 14, 16, 18, 20 and 24 weeks after intracerebral micro-
Z. Chiti, O.M. Knutsen, S. Betmouni, J.R.T. Greene   +3 more
doaj   +1 more source

Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

eLife, 2021
The hippocampus is critical for memory formation. The hypothalamic supramammillary nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 connection is critical for social memory, how this input acts on the local circuit is
Vincent Robert, Ludivine Therreau, Vivien Chevaleyre, Eude Lepicard, Cécile Viollet, Julie Cognet, Arthur JY Huang, Roman Boehringer, Denis Polygalov, Thomas J McHugh, Rebecca Ann Piskorowski   +10 more
doaj   +1 more source