Results 21 to 30 of about 179,365 (263)
MAGUKs, Synaptic Development, and Synaptic Plasticity [PDF]
The Neuroscientist, 2011 MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication.
Chan-Ying, Zheng +3 more
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Learning with delayed synaptic plasticity [PDF]
Proceedings of the Genetic and Evolutionary Computation Conference, 2019 The plasticity property of biological neural networks allows them to perform learning and optimize their behavior by changing their configuration. Inspired by biology, plasticity can be modeled in artificial neural networks by using Hebbian learning rules, i.e.
Anil Yaman +4 more
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Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
Cell & Bioscience, 2019 Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu +8 more
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Synaptic plasticity and phosphorylation [PDF]
Pharmacology & Therapeutics, 2006 A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity.
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Astrocytes: Orchestrating synaptic plasticity? [PDF]
Neuroscience, 2016 63 pages, 4 ...
de Pittà, Maurizio +2 more
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Nature Communications, 2016 During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret +4 more
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Neurobiology of Disease, 2006 We have conducted an integrated study of ME7 prion disease by examining the electrophysiological and neuropathological features of hippocampal slices from behaviourally characterised C57Bl/6J mice 12, 14, 16, 18, 20 and 24 weeks after intracerebral micro-
Z. Chiti +3 more
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Cell Calcium, 2005 The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell.
Cavazzini, M, Bliss, T, Emptage, N
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eLife, 2021 The hippocampus is critical for memory formation. The hypothalamic supramammillary nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 connection is critical for social memory, how this input acts on the local circuit is
Vincent Robert +10 more
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Nature Communications, 2020 Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating ...
Matt Udakis +4 more
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