Results 51 to 60 of about 1,092,184 (348)
Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring [PDF]
, 2009 Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal functional integration of brain processes.
Friston, K J +5 more
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Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.
, 2021 Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of ...
De Pittà, Maurizio, Brunel, Nicolas
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Branch-specific plasticity enables self-organization of nonlinear computation in single neurons [PDF]
, 2011 It has been conjectured that nonlinear processing in dendritic branches endows individual neurons with the capability to perform complex computational operations that are needed in order to solve for example the binding problem.
Maass, Wolfgang, Legenstein, Robert
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Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
Cell & Bioscience, 2019 Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu +8 more
doaj +1 more source
Stress gates an astrocytic energy reservoir to impair synaptic plasticity
Nature Communications, 2020 Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte bioenergetic control of synapses contributes to stress-impaired ...
Ciaran Murphy-Royal +12 more
semanticscholar +1 more source
Synaptic plasticity and phosphorylation [PDF]
Pharmacology & Therapeutics, 2006 A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity.
openaire +2 more sources
Astrocytes: Orchestrating synaptic plasticity? [PDF]
Neuroscience, 2016 63 pages, 4 ...
de Pittà, Maurizio +2 more
openaire +6 more sources
Nature Communications, 2016 During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret +4 more
doaj +1 more source
Neurobiology of Disease, 2006 We have conducted an integrated study of ME7 prion disease by examining the electrophysiological and neuropathological features of hippocampal slices from behaviourally characterised C57Bl/6J mice 12, 14, 16, 18, 20 and 24 weeks after intracerebral micro-
Z. Chiti +3 more
doaj +1 more source
Learning to Discriminate Through Long-Term Changes of Dynamical Synaptic Transmission [PDF]
, 2008 Short-term synaptic plasticity is modulated by long-term synaptic changes. There is, however, no general agreement on the computational role of this interaction.
Gundlfinger, Anja +10 more
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