Results 51 to 60 of about 316,392 (297)

Novelty producing synaptic plasticity [PDF]

Proceedings of the 2020 Genetic and Evolutionary Computation Conference Companion, 2020
A learning process with the plasticity property often requires reinforcement signals to guide the process. However, in some tasks (e.g. maze-navigation), it is very difficult (or impossible) to measure the performance of an agent (i.e. a fitness value) to provide reinforcements since the position of the goal is not known.
Yaman, Anil, Iacca, Giovanni, Mocanu, Decebal Constantin, Fletcher, George, Pechenizkiy, Mykola   +4 more
openaire   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Spiking Neural Networks for Inference and Learning: A Memristor-based Design Perspective [PDF]

, 2019
On metrics of density and power efficiency, neuromorphic technologies have the potential to surpass mainstream computing technologies in tasks where real-time functionality, adaptability, and autonomy are essential.
Abbott, Bartolozzi, Bartolozzi, Benjamin, Bi, Bohte, Detorakis, Faisal, Fouda, Fouda, Furber, Gerstner, Gerstner, Goldberg, Gütig, Hinton, Hopfield, Huayaney, Hyvärinen, Ielmini, Indiveri, Isomura, Jolivet, Katz, Kim, Levy, Li, Lillicrap, Maass, Mead, Merolla, Moreno-Bote, Naous, Neftci, Neftci, Neftci, Paille, Park, Pfister, Prezioso, Puglisi, Qiao, Querlioz, Savin, Saïghi, Schultz, Shouval, Tiago, Urbanczik, Wan, Wang, Williams, Woo, Xie, Yarom, Yu, Yu   +56 more
core   +2 more sources

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment

Scientific Reports
Head-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be used to emulate the visual experience of movement during head fixation, but a low inertia floating
Sarah A. Stuart, Jon Palacios-Filardo, Aleks Domanski, Matt Udakis, Ian Duguid, Matt W. Jones, Jack R. Mellor   +6 more
doaj   +1 more source

Nanoscale Mapping of Plasmonic Charge Transport in Nano‐Resonators Based on Resistive Switching Materials

Advanced Functional Materials, EarlyView.
In this strategy, a conductive nano‐probe is employed to induce nanoscale phase transitions and map the nanoscale conductivity and trap density of GST films. By utilizing the contrasting properties of phase‐change states, nano‐resonators are fabricated that exhibit plasmonic conduction and dramatically different transport characteristics.
Sunwoo Bang, Seunghyo Park, Shashank Shekhar, Yuhyeon Oh, Seunghun Hong   +4 more
wiley   +1 more source

Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia

Neurobiology of Disease, 2014
DYT1 dystonia is a movement disorder caused by a deletion in the C-terminal of the protein torsinA. It is unclear how torsinA mutation might disrupt cellular processes encoding motor activity, and whether this impairment occurs in specific brain regions.
G. Martella, M. Maltese, R. Nisticò, T. Schirinzi, G. Madeo, G. Sciamanna, G. Ponterio, A. Tassone, G. Mandolesi, V. Vanni, M. Pignatelli, P. Bonsi, A. Pisani   +12 more
doaj   +1 more source

Neural networks with dynamical synapses: from mixed-mode oscillations and spindles to chaos

, 2012
Understanding of short-term synaptic depression (STSD) and other forms of synaptic plasticity is a topical problem in neuroscience. Here we study the role of STSD in the formation of complex patterns of brain rhythms.
Goltsev, A. V., Lee, K. -E., Lopes, M. A., Mendes, J. F. F.   +3 more
core   +1 more source

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T., Baillie, G.S., Canton, D.A., Day, J.P., Gelman, I.H., Grimes, Q., Guercio, L.A., Havekes, R., Huang, T., Luczak, V., Nie, T., Park, A.J., Scott, J.D.   +12 more
core   +2 more sources