Results 71 to 80 of about 1,092,184 (348)

Synaptic plasticity and depression: New insights from stress and rapid-acting antidepressants

Nature Medicine, 2016
Depression is a common, devastating illness. Current pharmacotherapies help many patients, but high rates of a partial response or no response, and the delayed onset of the effects of antidepressant therapies, leave many patients inadequately treated ...
R. Duman, G. Aghajanian, G. Sanacora, J. Krystal   +3 more
semanticscholar   +1 more source

Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Synaptic plasticity in the hippocampus is important for learning and memory formation. In particular, homeostatic synaptic plasticity enables neurons to restore their activity levels in response to chronic neuronal activity changes.
Ye Wang, Wing Y. Fu, Kit Cheung, K. Hung, Congping Chen, Hongyan Geng, Wing-Ho Yung, Jia-Nan Y. Qu, Amy K. Y. Fu, Nancy Y. Ip   +9 more
semanticscholar   +1 more source

The actin-binding protein profilin II in neuronal plasticity [PDF]

, 2006
Activity-dependent plasticity in neurons involves changes in synaptic transmission and connectivity. These changes lead to altered neuronal circuit properties and are thought to underlie learning and memory.
Birbach, Andreas
core   +1 more source

Behavioral time scale synaptic plasticity underlies CA1 place fields

Science, 2017
A different form of synaptic plasticity How do synaptic or other neuronal changes support learning? This subject has been dominated by Hebb's postulate of synaptic change.
Katie C. Bittner, Aaron D. Milstein, Christine Grienberger, S. Romani, J. Magee   +4 more
semanticscholar   +1 more source

SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis

Scientific Reports, 2017
Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated.
Daniel L. Rocca, Kevin A. Wilkinson, Jeremy M. Henley   +2 more
doaj   +1 more source

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

Cell Reports, 2017
Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans, Sonam Gurung, Kevin A. Wilkinson, David J. Stephens, Jeremy M. Henley   +4 more
doaj   +1 more source

Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses

Nature Communications, 2020
In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez, Shuting Yin, Christian Schulze, John A. Hammer, Wolfgang Wagner, Thomas G. Oertner   +5 more
doaj   +1 more source

Noradrenergic signaling the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.

Nature Neuroscience, 2019
Microglia are the brain’s resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeostasis.
Rianne D. Stowell, G. Sipe, R. Dawes, Hanna N. Batchelor, K. A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, J. Bidlack, E. Brown, M. Sur, A. Majewska   +10 more
semanticscholar   +1 more source

SORN : a self-organizing recurrent neural network [PDF]

, 2009
Understanding the dynamics of recurrent neural networks is crucial for explaining how the brain processes information. In the neocortex, a range of different plasticity mechanisms are shaping recurrent networks into effective information processing ...
Pipa, Gordon, Andreea Lazar, Triesch, Jochen, Lazar, Andreea, Gordon Pipa, Jochen Triesch   +5 more
core   +1 more source

Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity

Frontiers in Synaptic Neuroscience, 2020
Experience-dependent learning and memory require multiple forms of plasticity at hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type ionotropic
Alicia M. Purkey, M. Dell'Acqua
semanticscholar   +1 more source