Results 91 to 100 of about 1,092,184 (348)

Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses [PDF]

, 2017
Recent studies demonstrate that chronic administration of the widely used antidepressant fluoxetine (FLX) promotes neurogenesis, synaptogenesis and synaptic plasticity in the adult hippocampus, cortex and amygdala.
Eero Castrén, Taira, Tomi, Dina Popova, Castren, Eero, Tomi Taira, Popova, Dina   +5 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Connectivity reflects coding: A model of voltage-based spike-timing-dependent-plasticity with homeostasis [PDF]

, 2009
Electrophysiological connectivity patterns in cortex often show a few strong connections in a sea of weak connections. In some brain areas a large fraction of strong connections are bidirectional, in others they are mainly unidirectional.
Claudia Clopath, Lars Büsing, Wulfram Gerstner, Eleni Vasilaki   +3 more
core  

Synaptic plasticity rules with physiological calcium levels [PDF]

, 2020
International audienceSpike-timing-dependent plasticity (STDP) is considered as a primary mechanism underlying formation of new memories during learning.
Aljadeff, Johnatan, Brunel, Nicolas, Debanne, Dominique, Inglebert, Yanis, Yanis Inglebert, Nicolas Brunel, Dominique Debanne, Johnatan Aljadeff   +7 more
core   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Synaptic Plasticity: Stairway to Memory

Japanese Journal of Pharmacology, 1995
Since the idea that memory is associated with alterations in synaptic strength was accepted, studies on the cellular and molecular mechanisms responsible for the plastic changes in neurons have attracted wide interest in the scientific community. Recent studies on memory processes have also pointed out some unifying themes emerging from a wide range of
Jodar, Luis, Kaneto, Hiroshi
openaire   +3 more sources

Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment

Scientific Reports
Head-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be used to emulate the visual experience of movement during head fixation, but a low inertia floating
Sarah A. Stuart, Jon Palacios-Filardo, Aleks Domanski, Matt Udakis, Ian Duguid, Matt W. Jones, Jack R. Mellor   +6 more
doaj   +1 more source

Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology

International Journal of Molecular Sciences, 2019
Studies of brain network connectivity improved understanding on brain changes and adaptation in response to different pathologies. Synaptic plasticity, the ability of neurons to modify their connections, is involved in brain network remodeling following ...
Mario Stampanoni Bassi, E. Iezzi, L. Gilio, D. Centonze, F. Buttari   +4 more
semanticscholar   +1 more source

Intermediate Resistive State in Wafer‐Scale Vertical MoS2 Memristors Through Lateral Silver Filament Growth for Artificial Synapse Applications

Advanced Functional Materials, EarlyView.
In MOCVD MoS2 memristors, a current compliance‐regulated Ag filament mechanism is revealed. The filament ruptures spontaneously during volatile switching, while subsequent growth proceeds vertically through the MoS2 layers and then laterally along the van der Waals gaps during nonvolatile switching.
Yuan Fa, Milan Buttberg, Ke Ran, Rana Walied Ahmad, Dennis Braun, Lukas Völkel, Jimin Lee, Sofía Cruces, Bart Macco, Bárbara Canto, Holger Lerch, Thorsten Wahlbrink, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Zhenxing Wang, Ilia Valov, Stephan Menzel, Max C. Lemme   +19 more
wiley   +1 more source

Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia

Neurobiology of Disease, 2014
DYT1 dystonia is a movement disorder caused by a deletion in the C-terminal of the protein torsinA. It is unclear how torsinA mutation might disrupt cellular processes encoding motor activity, and whether this impairment occurs in specific brain regions.
G. Martella, M. Maltese, R. Nisticò, T. Schirinzi, G. Madeo, G. Sciamanna, G. Ponterio, A. Tassone, G. Mandolesi, V. Vanni, M. Pignatelli, P. Bonsi, A. Pisani   +12 more
doaj   +1 more source