Results 81 to 90 of about 1,092,184 (348)

Feedforward inhibition and synaptic scaling - two sides of the same coin? [PDF]

, 2012
Feedforward inhibition and synaptic scaling are important adaptive processes that control the total input a neuron can receive from its afferents. While often studied in isolation, the two have been reported to co-occur in various brain regions.
Cristina Savin, Keck, Christian, Savin Cristina, Lücke, Jörg, Cristina Savin (175862), Jörg Lücke (175863), Christian Keck (175861), Christian Keck, Jörg Lücke, Savin, Cristina, Keck Christian, Lücke Jörg   +11 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus

Cell Reports, 2016
Place cell firing patterns reactivated during hippocampal sharp-wave ripples (SWRs) in rest or sleep are thought to induce synaptic plasticity and thereby promote the consolidation of recently encoded information.
Josef H.L.P. Sadowski, Matthew W. Jones, Jack R. Mellor   +2 more
doaj   +1 more source

Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Nature Communications, 2021
In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor   +7 more
doaj   +1 more source

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Huang, T., Day, Jonathan P., Day, Jonathan P, Baillie, George S., Guercio, L.A., Luczak, V., Nie, T., Scott, J.D., Guercio, Leonardo A., Baillie, G.S., Abel, T., Gelman, I.H., Park, Alan J, Canton, David A., Scott, John D., Havekes, R., Nie, Ting, Gelman, Irwin H, Canton, D.A., Park, Alan J., Grimes, Quinn, Grimes, Q., Luczak, Vincent G, Havekes, Robbert, Park, A.J., Guercio, Leonardo A, Baillie, George S, Abel, Ted, Gelman, Irwin H., Luczak, Vincent, Day, J.P., Canton, David A, Huang, Ted   +32 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]

, 2015
Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Rusakov, DA, Heller, JP
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Stochastic synaptic plasticity in deterministic aVLSI networks of spiking neurons [PDF]

, 2001
Chicca E, Fusi S. Stochastic synaptic plasticity in deterministic aVLSI networks of spiking neurons. In: Rattay F, ed. Proceedings of the World Congress on Neuroinformatics.
Fusi, S., Chicca, Elisabetta ; https://orcid.org/, Rattay, Frank   +2 more
core  

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source