Results 41 to 50 of about 1,821,300 (301)

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse [PDF]

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Isabel Dean, Frances A. Edwards, Dean, I., Susan J. Robertson, Edwards, F.A., Robertson, S.J.   +5 more
core   +1 more source

Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus.

PLoS ONE, 2010
Methamphetamine (METH) is an addictive psychostimulant whose societal impact is on the rise. Emerging evidence suggests that psychostimulants alter synaptic plasticity in the brain--which may partly account for their adverse effects.
Jarod Swant, Sanika Chirwa, Gregg Stanwood, Habibeh Khoshbouei   +3 more
doaj   +1 more source

Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]

, 2015
The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte, Miles, Gareth Brian, Nascimento, Filipe   +2 more
core   +1 more source

Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission

IBRO Reports, 2019
Amyloid β protein (Aβ) is closely related to the progression of Alzheimer's disease because senile plaques consisting of Aβ cause synaptic depression and synaptic abnormalities.
Kohei Oyabu, Hiroki Kiyota, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki   +5 more
doaj   +1 more source

Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

eLife, 2021
The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders.
Kang-Ying Qian, Wan-Xin Zeng, Yue Hao, Xian-Ting Zeng, Haowen Liu, Lei Li, Lili Chen, Fu-min Tian, Cindy Chang, Qi Hall, Chun-Xue Song, Shangbang Gao, Zhitao Hu, Joshua M Kaplan, Qian Li, Xia-Jing Tong   +15 more
doaj   +1 more source

miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity [PDF]

, 2013
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function.
Mistry, Rajen B., McKenzie, Colin, Palygin, O, Palygin, Oleg, Hutvagner Gyorgy, Remenyi Judit, Mistry Rajen B., Remenyi, J, Yuriy Pankratov, Pankratov Yuriy, Mirjam W M van den Bosch, McKenzie, C, Andrew Macdonald, Frenguelli Bruno G., Hutvagner, G, van den Bosch, Mirjam W. M., Pankratov, Yuriy, van den Bosch, MWM, Mistry, RB, Gyorgy Hutvagner, Judit Remenyi, Arthur J. Simon C., Macdonald, Andrew, Macdonald, A, Colin McKenzie, Frenguelli, BG, Remenyi, Judit, Hutvagner, Gyorgy, Arthur, J. Simon C., Frenguelli, Bruno G., Macdonald Andrew, van den Bosch Mirjam W. M., Rajen B Mistry, Oleg Palygin, Bruno G Frenguelli, Palygin Oleg, Arthur, J. Simon C.; id_orcid, J Simon C Arthur, Arthur, JSC, Pankratov, Y, McKenzie Colin   +40 more
core   +1 more source

mGluR-dependent synaptic plasticity in drug-seeking.

Frontiers in Pharmacology, 2012
A primary feature of drug addiction is the compulsive use despite negative consequences. A general consensus is emerging on the capacity of addictive substances to co-opt synaptic transmission and synaptic plasticity in brain circuits which are involved ...
Camilla eBellone, Manuel eMameli, Manuel eMameli, Manuel eMameli   +3 more
doaj   +1 more source

Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

eLife, 2022
Neurotransmitters are generated by de novo synthesis and are essential for sustained, high-frequency synaptic transmission. Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc ...
Yongchao Han, Lei Peng, Tao Wang
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
Beato, M., Marco Beato, Annalisa Scimemi, Scimemi, A.   +3 more
core   +1 more source

Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn

Biochemistry and Biophysics Reports, 2021
Riluzole (2-amino-6-(trifluoromethoxy)benzothiazole) is a drug known for its inhibitory effect on glutamatergic transmission and its anti-nociceptive and anti-allodynic effects in neuropathic pain rat models.
Ryo Taiji, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Shunji Tsutsui, Terumasa Nakatsuka, Hiroshi Yamada   +6 more
doaj   +1 more source