Results 31 to 40 of about 1,906,626 (299)

Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission

IBRO Reports, 2019
Amyloid β protein (Aβ) is closely related to the progression of Alzheimer's disease because senile plaques consisting of Aβ cause synaptic depression and synaptic abnormalities.
Kohei Oyabu, Hiroki Kiyota, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Katsunori Iwasaki   +5 more
doaj   +1 more source

Septotemporal variation in modulation of synaptic transmission, paired-pulse ratio and frequency facilitation/depression by adenosine and GABA receptors in the rat hippocampus

Brain and Neuroscience Advances, 2022
Short-term synaptic plasticity represents a fundamental mechanism in neural information processing and is regulated by neuromodulators. Here, using field recordings from the CA1 region of adult rat hippocampal slices, we show that excitatory synaptic ...
Maria A. Samara, George D. Oikonomou, George Trompoukis, Georgia Madarou, Maria Adamopoulou, Costas Papatheodoropoulos   +5 more
doaj   +1 more source

Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

eLife, 2021
The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders.
Kang-Ying Qian, Wan-Xin Zeng, Yue Hao, Xian-Ting Zeng, Haowen Liu, Lei Li, Lili Chen, Fu-min Tian, Cindy Chang, Qi Hall, Chun-Xue Song, Shangbang Gao, Zhitao Hu, Joshua M Kaplan, Qian Li, Xia-Jing Tong   +15 more
doaj   +1 more source

Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]

, 2012
Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Schmitt, L. Ian, R. E. Sims, Sims, Robert E., P. G. Haydon, Dale, Nicholas, Sims, Robert, Haydon, Philip G, L. I. Schmitt, N. Dale, Schmitt, L Ian   +9 more
core   +1 more source

mGluR-dependent synaptic plasticity in drug-seeking.

Frontiers in Pharmacology, 2012
A primary feature of drug addiction is the compulsive use despite negative consequences. A general consensus is emerging on the capacity of addictive substances to co-opt synaptic transmission and synaptic plasticity in brain circuits which are involved ...
Camilla eBellone, Manuel eMameli, Manuel eMameli, Manuel eMameli   +3 more
doaj   +1 more source

Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

eLife, 2022
Neurotransmitters are generated by de novo synthesis and are essential for sustained, high-frequency synaptic transmission. Histamine, a monoamine neurotransmitter, is synthesized through decarboxylation of histidine by histidine decarboxylase (Hdc ...
Yongchao Han, Lei Peng, Tao Wang
doaj   +1 more source

Myosin VI contributes to synaptic transmission and development at the Drosophila neuromuscular junction [PDF]

, 2011
Background: Myosin VI, encoded by jaguar (jar) in Drosophila melanogaster, is a unique member of the myosin superfamily of actin-based motor proteins.
Majumdar, D., Campbell, S., Stewart, B.A., Kisiel, M.   +3 more
core   +1 more source

Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn

Biochemistry and Biophysics Reports, 2021
Riluzole (2-amino-6-(trifluoromethoxy)benzothiazole) is a drug known for its inhibitory effect on glutamatergic transmission and its anti-nociceptive and anti-allodynic effects in neuropathic pain rat models.
Ryo Taiji, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Shunji Tsutsui, Terumasa Nakatsuka, Hiroshi Yamada   +6 more
doaj   +1 more source

Learning to Discriminate Through Long-Term Changes of Dynamical Synaptic Transmission [PDF]

, 2008
Short-term synaptic plasticity is modulated by long-term synaptic changes. There is, however, no general agreement on the computational role of this interaction.
Gundlfinger, Anja, Gundlfinger, A., Thurley, K., Schmitz, Dietmar, Thurley, Kay, Leibold, Christian, Kempter, Richard, Leibold, C., Kempter, R., Bendels, Michael H. K., Schmitz, D.   +10 more
core   +1 more source

NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation

Nature Communications
Efficient control of feeding behavior requires the coordinated adjustment of complex motivational and affective neurocircuits. Neuropeptides from energy-sensing hypothalamic neurons are potent feeding modulators, but how these endogenous signals shape ...
Stephan Dodt, Noah V. Widdershooven, Marie-Luise Dreisow, Lisa Weiher, Lukas Steuernagel, F. Thomas Wunderlich, Jens C. Brüning, Henning Fenselau   +7 more
doaj   +1 more source