Results 11 to 20 of about 1,906,626 (299)

Model-Based Inference of Synaptic Transmission [PDF]

Frontiers in Synaptic Neuroscience, 2019
Synaptic computation is believed to underlie many forms of animal behavior. A correct identification of synaptic transmission properties is thus crucial for a better understanding of how the brain processes information, stores memories and learns ...
Ola Bykowska, Camille Gontier, Anne-Lene Sax, David W. Jia, Milton Llera Montero, Milton Llera Montero, Alex D. Bird, Alex D. Bird, Conor Houghton, Jean-Pascal Pfister, Jean-Pascal Pfister, Rui Ponte Costa, Rui Ponte Costa   +12 more
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Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons [PDF]

Molecular Brain, 2021
In addition to providing structural support, caveolin-1 (Cav1), a component of lipid rafts, including caveolae, in the plasma membrane, is involved in various cellular mechanisms, including signal transduction. Although pre-synaptic membrane dynamics and
Soulmee Koh, Wongyoung Lee, Sang Myun Park, Sung Hyun Kim   +3 more
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Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice [PDF]

, 2010
Background Alzheimer disease (AD) is a neurodegenerative disorder for which there is no cure. We have investigated synaptic plasticity in area CA1 in a novel AD mouse model (APPPS1-21) which expresses the Swedish mutation of APP and the L166P mutation of
Holscher, Christian, Hamilton, A., Gengler, Simon   +2 more
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Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
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Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Todorov, Boyan, Furukawa, Keiko, Furukawa, K., Plomp, J.J., Verschuuren, Jan J., Willison, H.J., Furukawa, Koichi, Plomp, Jaap J., Jacobs, B.C., Todorov, B., Willison, Hugh J., Jacobs, Bart C., Zitman, F.M.P., Verschuuren, J.J., Zitman, Femke M.P.   +14 more
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Postnatal development of intrinsic and synaptic properties transforms signaling in the Layer 5 excitatory neural network of the visual cortex [PDF]

, 2011
Information flow in neocortical circuits is regulated by two key parameters: intrinsic neuronal properties and the short-term activity-dependent plasticity of synaptic transmission.
Etherington, Sarah J., S. J. Etherington, S. R. Williams, Etherington, S.J., Williams, S.R., Williams, Stephen R.   +5 more
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Chronic Ethanol Exposure Enhances Facial Stimulation-Evoked Mossy Fiber–Granule Cell Synaptic Transmission via GluN2A Receptors in the Mouse Cerebellar Cortex

Frontiers in Systems Neuroscience, 2021
Sensory information is transferred to the cerebellar cortex via the mossy fiber–granule cell (MF–GC) pathway, which participates in motor coordination and motor learning.
Bing-Xue Li, Bing-Xue Li, Guang-Hui Dong, Guang-Hui Dong, Hao-Long Li, Hao-Long Li, Jia-Song Zhang, Jia-Song Zhang, Yan-Hua Bing, Chun-Ping Chu, Chun-Ping Chu, Song-Biao Cui, De-Lai Qiu, De-Lai Qiu   +13 more
doaj   +1 more source

Conversion of Fibroblasts to Neural Cells by p53 Depletion

Cell Reports, 2014
Conversion from fibroblasts to neurons has recently been successfully induced. However, the underlying mechanisms are poorly understood. Here, we find that depletion of p53 alone converts fibroblasts into all three major neural lineages.
Di Zhou, Zhen Zhang, Li-Ming He, Juan Du, Fan Zhang, Chong-Kui Sun, Yu Zhou, Xiao-Wei Wang, Ge Lin, Ke-Ming Song, Ling-Gang Wu, Qin Yang   +11 more
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MSK1 regulates homeostatic and experience-dependent synaptic plasticity [PDF]

, 2012
The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response ...
Frenguelli, BrunoG., Corrêa, SAL, McKenzie, Colin, Palygin, O, Palygin, Oleg, Martin, KJ, Arthur, J.S., McKelvey, Kim, Hunter, CJ, Morris, R. G. M. (Richard G. M.), Morris, R.G., Morris, RGM, McKenzie, C, Hunter, Christopher J., Wauters, Sandrine C., Pankratov, Yuriy, Hunter, C.J., Wauters, S.C., Wauters, SC, Wauters, Sandrine, Martin, K.J., Arthur, J.Simon C.; id_orcid, Palygin, O., Frenguelli, BG, Corrêa, Sonia A.L., Corrêa, Sônia A. L., Arthur, J. Simon C., Frenguelli, Bruno G., Morris, Richard G. M., Frenguelli, B.G., Pankratov, Y., Martin, Kirsty J., McKelvey, Kim M. (Kim Martin), McKenzie, C., Arthur, JSC, McKelvey, K., Pankratov, Y, McKelvey, K   +37 more
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Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice

Scientific Reports, 2023
The noradrenergic fibers of the locus coeruleus, together with mossy fibers and climbing fibers, comprise the three types of cerebellar afferents that modulate the cerebellar neuronal circuit.
Jun-Ya Wang, Wen-Cai Weng, Ting-Qi Wang, Yue Liu, De-Lai Qiu, Mao-Cheng Wu, Chun-Ping Chu   +6 more
doaj   +1 more source