Results 11 to 20 of about 523,574 (246)
Volume transmission signalling via astrocytes [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 The influence of astrocytes on synaptic function has been increasingly studied, owing to the discovery of both gliotransmission and morphological ensheathment of synapses. While astrocytes exhibit at best modest membrane potential fluctuations, activation of G-protein coupled receptors (GPCRs) leads to a prominent elevation of intracellular calcium ...
Hirase, Hajime +4 more
openaire +3 more sources
Mechanisms of neuromodulatory volume transmission [PDF]
Molecular PsychiatryAbstractA wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs from classical synaptic transmission in important ways. In synaptic transmission, vesicles rapidly fuse in response to action potentials and release their transmitter content.
Özge D. Özçete +2 more
openaire +3 more sources
Astrocytes and extracellular matrix in extrasynaptic volume transmission [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Volume transmission is a form of intercellular communication that does not require synapses; it is based on the diffusion of neuroactive substances across the brain extracellular space (ECS) and their binding to extrasynaptic high-affinity receptors on neurons or glia.
Lýdia, Vargová, Eva, Syková
openaire +3 more sources
Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine [PDF]
Cell Reports, 2019 Summary: In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons.
Chun Chen +5 more
doaj +2 more sources
Volume transmission of beta-endorphin via the cerebrospinal fluid; a review [PDF]
Fluids and Barriers of the CNS, 2012 There is increasing evidence that non-synaptic communication by volume transmission in the flowing CSF plays an important role in neural mechanisms, especially for extending the duration of behavioral effects.
Veening Jan G +2 more
doaj +2 more sources
Journal of Integrative Neuroscience, 2022 Here we present a complex hypothesis about the psychosomatic mechanism of serotonergic psychedelics. Serotonergic psychedelics affect gut microbes that produce a temporary increase of 5-HT by their host enterochromaffin cells (ECs).
Noémi Császár-Nagy +2 more
doaj +1 more source
Brain Structure and Function: Insights from Chemical Neuroanatomy
Life, 2023 We present a brief historical and epistemological outline of investigations on the brain’s structure and functions. These investigations have mainly been based on the intermingling of chemical anatomy, new techniques in the field of microscopy and ...
Luigi F. Agnati +4 more
doaj +1 more source
Selective WGA uptake in the hippocampus from the locus coeruleus of DBH-WGA transgenic mice
Frontiers in Behavioral Neuroscience, 2012 We generated transgenic mice in which a transsynaptic tracer, wheat germ agglutinin (WGA), was specifically expressed in the locus coeruleus neurons under the control of the dopamine-β-hydroxylase gene promoter. WGA protein was produced in more than 95%
Susan G eWalling +4 more
doaj +1 more source
Nitric Oxide Signaling in the Auditory Pathway
Frontiers in Neural Circuits, 2021 Nitric oxide (NO) is of fundamental importance in regulating immune, cardiovascular, reproductive, neuromuscular, and nervous system function. It is rapidly synthesized and cannot be confined, it is highly reactive, so its lifetime is measured in seconds.
Conny Kopp-Scheinpflug, Ian D. Forsythe
doaj +1 more source
Volume Transmission in the Brain: Beyond the Synapse [PDF]
The Journal of Neuropsychiatry and Clinical Neurosciences, 2014 A better understanding of volume transmission is important in neuropsychiatry, as this is now believed to be a major mode of action for many neuroactive substances, including the modulatory neurotransmitters and many psychiatric medications.
Katherine H, Taber, Robin A, Hurley
openaire +2 more sources