Results 11 to 20 of about 6,877,005 (268)
Mechanisms of neuromodulatory volume transmission. [PDF]
Mol PsychiatryAbstractA wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs from classical synaptic transmission in important ways. In synaptic transmission, vesicles rapidly fuse in response to action potentials and release their transmitter content.
Özçete ÖD, Banerjee A, Kaeser PS.
europepmc +4 more sources
Volume transmission signalling via astrocytes. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2014 The influence of astrocytes on synaptic function has been increasingly studied, owing to the discovery of both gliotransmission and morphological ensheathment of synapses. While astrocytes exhibit at best modest membrane potential fluctuations, activation of G-protein coupled receptors (GPCRs) leads to a prominent elevation of intracellular calcium ...
Hirase H +4 more
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Astrocytes and extracellular matrix in extrasynaptic volume transmission. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2014 Volume transmission is a form of intercellular communication that does not require synapses; it is based on the diffusion of neuroactive substances across the brain extracellular space (ECS) and their binding to extrasynaptic high-affinity receptors on neurons or glia.
Vargová L, Syková E.
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Volume Transmission in the Brain: Beyond the Synapse [PDF]
The Journal of Neuropsychiatry and Clinical Neurosciences, 2014 A better understanding of volume transmission is important in neuropsychiatry, as this is now believed to be a major mode of action for many neuroactive substances, including the modulatory neurotransmitters and many psychiatric medications.
Katherine H, Taber, Robin A, Hurley
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From synaptically localized to volume transmission by nitric oxide [PDF]
The Journal of Physiology, 2015 AbstractNitric oxide (NO) functions widely as a transmitter/diffusible second messenger in the central nervous system, exerting physiological effects in target cells by binding to specialized guanylyl cyclase‐coupled receptors, resulting in cGMP generation.
J. Garthwaite
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Volume Transmission–Mediated Encephalopathies [PDF]
Archives of Neurology, 2012 There is strong evidence that the composition of cerebrospinal fluid (CSF) influences brain development, neurogenesis, and behavior. The bidirectional exchange of CSF and interstitial fluid (ISF) across the ependymal and pia-glial membranes is required for these phenomena to occur.
Hans-Peter, Hartung, Marcel, Dihné
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Frontiers in Physiology, 2012 We review the evidence of exocytosis from extrasynaptic sites in the soma, dendrites and axonal varicosities of central and peripheral neurons of vertebrates and invertebrates, and how it may contribute to signaling in the nervous system.
Citlali eTrueta +1 more
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Probing Neuropeptide Volume Transmission In Vivo by Simultaneous Near-Infrared Light-Triggered Release and Optical Sensing. [PDF]
Angew Chem Int Ed Engl, 2022 Neuropeptides are abundant signaling molecules in the central nervous system. Yet remarkably little is known about their spatiotemporal spread and biological activity.
Xiong H +18 more
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<i>Ascaris suum</i> Informs Extrasynaptic Volume Transmission in Nematodes. [PDF]
ACS Chem Neurosci, 2021 Neural circuit synaptic connectivities (the connectome) provide the anatomical foundation for our understanding of nematode nervous system function. However, other nonsynaptic routes of communication are known in invertebrates including extrasynaptic ...
Atkinson LE +14 more
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Dopamine release, diffusion and uptake: A computational model for synaptic and volume transmission. [PDF]
PLoS Comput Biol, 2020 Computational modeling of dopamine transmission is challenged by complex underlying mechanisms. Here we present a new computational model that (I) simultaneously regards release, diffusion and uptake of dopamine, (II) considers multiple terminal release ...
Wiencke K +4 more
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