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Cell–Cell Mechanical Communication in Cancer

Cellular and Molecular Bioengineering, 2018
Communication between cancer cells enables cancer progression and metastasis. While cell-cell communication in cancer has primarily been examined through chemical mechanisms, recent evidence suggests that mechanical communication through cell-cell junctions and cell-ECM linkages is also an important mediator of cancer progression.
Samantha C. Schwager, Paul V. Taufalele, Cynthia A. Reinhart-King   +2 more
openaire   +5 more sources

Single-nucleus and spatial transcriptomics reveal intestinal cellular heterogeneity, differentiation, and cell communication mechanisms in SAP-induced intestinal injury [PDF]

Frontiers in Immunology
BackgroundAcute pancreatitis (AP) ranges from mild to severe, and severe disease frequently causes multi-organ damage, with intestinal injury being a major complication. The mechanisms underlying SAP-induced intestinal injury remain unclear, particularly
Lechang Zhang, Changqin Xu, Tong Su, Tong Xiao, Xu Yi, Yuemin Feng, Jing Wang, Shulei Zhao   +7 more
doaj   +2 more sources

Controlling Synthetic Cell-Cell Communication [PDF]

Frontiers in Molecular Biosciences, 2022
Synthetic cells, which mimic cellular function within a minimal compartment, are finding wide application, for instance in studying cellular communication and as delivery devices to living cells. However, to fully realise the potential of synthetic cells, control of their function is vital.
Smith, J, Chowdhry, R, Booth, M
openaire   +4 more sources

Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism

Frontiers in Aging Neuroscience, 2023
IntroductionStem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear.
Kevin S. Chen, Kevin S. Chen, Kevin S. Chen, Mohamed H. Noureldein, Mohamed H. Noureldein, Lisa M. McGinley, Lisa M. McGinley, John M. Hayes, John M. Hayes, Diana M. Rigan, Diana M. Rigan, Jacquelin F. Kwentus, Jacquelin F. Kwentus, Shayna N. Mason, Shayna N. Mason, Faye E. Mendelson, Faye E. Mendelson, Masha G. Savelieff, Eva L. Feldman, Eva L. Feldman   +19 more
doaj   +1 more source

Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation

BMC Neuroscience, 2021
Background Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate ...
Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su, Anna Walczewska   +4 more
doaj   +1 more source

Dissecting Immunosuppressive Cell Communication Patterns Reveals JunB Proto-Oncogene (JUNB) Shaping a Non-Inflamed Tumor Microenvironment

Frontiers in Genetics, 2022
Background: Immunosuppressive cell interactions are responsible for tumor progression and metastasis, as well as anti-tumor immune dysfunction. However, the communication pattern remains unclear.Methods: We first integrated two single-cell RNA-seq ...
Hualin Chen, Gang Chen
doaj   +1 more source

Synchronization of oscillatory growth prepares fungal hyphae for fusion

eLife, 2023
Communication is crucial for organismic interactions, from bacteria, to fungi, to humans. Humans may use the visual sense to monitor the environment before starting acoustic interactions.
Valentin Wernet, Marius Kriegler, Vojtech Kumpost, Ralf Mikut, Lennart Hilbert, Reinhard Fischer   +5 more
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Exosome-Mediated Therapeutic Strategies for Management of Solid and Hematological Malignancies

Cells, 2022
Exosomes are small membrane vesicles of endocytic origin containing cytokines, RNAs, growth factors, proteins, lipids, and metabolites. They have been identified as fundamental intercellular communication controllers in several diseases and an enormous ...
Alessandro Allegra, Claudia Petrarca, Mario Di Gioacchino, Marco Casciaro, Caterina Musolino, Sebastiano Gangemi   +5 more
doaj   +1 more source

Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases

Frontiers in Cell and Developmental Biology, 2021
Exosomes are lipid bilayer vesicles released by multiple cell types. These bioactive vesicles are gradually becoming a leading star in intercellular communication involving in various pathological and physiological process.
Hui Shi, Min Wang, Yaoxiang Sun, Dakai Yang, Wenrong Xu, Hui Qian   +5 more
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Fibrin, Bone Marrow Cells and Macrophages Interactively Modulate Cardiomyoblast Fate

Biomedicines, 2022
Interactions between macrophages, cardiac cells and the extracellular matrix are crucial for cardiac repair following myocardial infarction (MI). We hypothesized that cell-based treatments might modulate these interactions.
Inês Borrego, Aurélien Frobert, Guillaume Ajalbert, Jérémy Valentin, Cyrielle Kaltenrieder, Benoît Fellay, Michael Stumpe, Stéphane Cook, Joern Dengjel, Marie-Noëlle Giraud   +9 more
doaj   +1 more source