Results 21 to 30 of about 9,983,343 (204)

A Global Regulatory Network for Dysregulated Gene Expression and Abnormal Metabolic Signaling in Immune Cells in the Microenvironment of Graves’ Disease and Hashimoto’s Thyroiditis

Frontiers in Immunology, 2022
BackgroundAlthough the pathogenetic mechanisms of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) have been elucidated, the molecular mechanisms by which the abnormal immune function of cellular subpopulations trigger an autoimmune attack on ...
Haitao Zheng, Jie Xu, Yongli Chu, Wenzhou Jiang, Wenjie Yao, Shaowen Mo, Xicheng Song, Jin Zhou   +7 more
doaj   +1 more source

Conservation of Cell Communication Systems in Invertebrate Host–Defence Mechanisms: Possible Role in Immunity and Disease

Biology, 2020
Innate immunity is continuously revealing multiple and highly conserved host–defence mechanisms. Studies on mammalian immunocytes are showing different communication systems that may play a role in coordinating innate immune responses also in ...
Manon Auguste, Teresa Balbi, Caterina Ciacci, Laura Canesi   +3 more
doaj   +1 more source

Multiplexing cell-cell communication

Molecular Systems Biology, 2019
Abstract The engineering of advanced multicellular behaviors, such as the programmed growth of biofilms or tissues, requires cells to communicate multiple aspects of physiological information. Unfortunately, few cell-cell communication systems have been developed for synthetic biology.
John T Sexton, Jeffrey J Tabor
openaire   +4 more sources

Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism

Frontiers in Aging Neuroscience, 2023
IntroductionStem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear.
Kevin S. Chen, Kevin S. Chen, Kevin S. Chen, Mohamed H. Noureldein, Mohamed H. Noureldein, Lisa M. McGinley, Lisa M. McGinley, John M. Hayes, John M. Hayes, Diana M. Rigan, Diana M. Rigan, Jacquelin F. Kwentus, Jacquelin F. Kwentus, Shayna N. Mason, Shayna N. Mason, Faye E. Mendelson, Faye E. Mendelson, Masha G. Savelieff, Eva L. Feldman, Eva L. Feldman   +19 more
doaj   +1 more source

Cell Communications in the Heart [PDF]

Circulation, 2010
Cardiovascular disease is a leading cause of death worldwide. Nearly 2400 Americans die of cardiac causes each day, 1 death every 37 seconds.1 Thus, the heart still reigns supreme: “[F]oundation of their [animals’] life, the sovereign of everything within them, the sun of their microcosm, that on which all growth depends, from which all power proceeds”
Daniela, Tirziu, Frank J, Giordano, Michael, Simons   +2 more
openaire   +2 more sources

Exosomes are natural carriers of exogenous siRNA to human cells in vitro [PDF]

, 2013
© 2013 Shtam et al. Background: Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA.
Varfolomeeva, EY, Kovalev, RA, Makarov, EM, Kil, YV, Filatov, MV, Shtam, TA   +5 more
core   +1 more source

The Expanding Role of Vesicles Containing Aquaporins

Cells, 2018
In animals and plants, membrane vesicles containing proteins have been defined as key for biological systems involving different processes such as trafficking or intercellular communication.
M Carmen Martinez-Ballesta, Paula Garcia-Ibañez, Lucía Yepes-Molina, Juan José Rios, Micaela Carvajal   +4 more
doaj   +1 more source

Dissecting Immunosuppressive Cell Communication Patterns Reveals JunB Proto-Oncogene (JUNB) Shaping a Non-Inflamed Tumor Microenvironment

Frontiers in Genetics, 2022
Background: Immunosuppressive cell interactions are responsible for tumor progression and metastasis, as well as anti-tumor immune dysfunction. However, the communication pattern remains unclear.Methods: We first integrated two single-cell RNA-seq ...
Hualin Chen, Gang Chen
doaj   +1 more source

Synchronization of oscillatory growth prepares fungal hyphae for fusion

eLife, 2023
Communication is crucial for organismic interactions, from bacteria, to fungi, to humans. Humans may use the visual sense to monitor the environment before starting acoustic interactions.
Valentin Wernet, Marius Kriegler, Vojtech Kumpost, Ralf Mikut, Lennart Hilbert, Reinhard Fischer   +5 more
doaj   +1 more source

Exosome-Mediated Therapeutic Strategies for Management of Solid and Hematological Malignancies

Cells, 2022
Exosomes are small membrane vesicles of endocytic origin containing cytokines, RNAs, growth factors, proteins, lipids, and metabolites. They have been identified as fundamental intercellular communication controllers in several diseases and an enormous ...
Alessandro Allegra, Claudia Petrarca, Mario Di Gioacchino, Marco Casciaro, Caterina Musolino, Sebastiano Gangemi   +5 more
doaj   +1 more source