Results 1 to 10 of about 176,486 (297)

Intraduodenal Delivery of Exosome-Loaded SARS-CoV-2 RBD mRNA Induces a Neutralizing Antibody Response in Mice

Vaccines, 2023
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has presented numerous challenges to global health.
Quan Zhang, Miao Wang, Chunle Han, Zhijun Wen, Xiaozhu Meng, Dongli Qi, Na Wang, Huanqing Du, Jianhong Wang, Lu Lu, Xiaohu Ge   +10 more
doaj   +1 more source

Neutrophil membrane engineered HucMSC sEVs alleviate cisplatin-induced AKI by enhancing cellular uptake and targeting

Journal of Nanobiotechnology, 2022
Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEVs) have been demonstrated as a therapeutic agent to prevent and treat cisplatin-induced acute kidney injury (AKI).
Peipei Wu, Yuting Tang, Can Jin, Min Wang, Linli Li, Zhong Liu, Hui Shi, Zixuan Sun, Xiaomei Hou, Wenya Chen, Wenrong Xu, Hui Qian   +11 more
doaj   +1 more source

MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

Stem Cells International, 2022
Mesenchymal stem cell- (MSC-) derived extracellular vesicles (EVs) serving as delivery system have attracted extensive research interest, especially in cancer therapy.
Benshuai You, Can Jin, Jiaxin Zhang, Min Xu, Wenrong Xu, Zixuan Sun, Hui Qian   +6 more
doaj   +1 more source

Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy

Stem Cells International, 2021
Exosomes have emerged as a new drug delivery system. In particular, exosomes derived from mesenchymal stem cells (MSCs) have been extensively studied because of their tumor-homing ability and yield advantages.
Zixuan Sun, Jiaxin Zhang, Jiali Li, Mi Li, Jing Ge, Peipei Wu, Benshuai You, Hui Qian   +7 more
doaj   +1 more source

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
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Orally Administered Bifidobacterium adolescentis Diminishes Serum Glutamate Concentration in Mice

Microbiology Spectrum, 2023
Several studies have described the contribution of glutamate-transforming microbiota to the development of chronic ailments. For instance, the blood concentration of glutamate is higher in some patients with fibromyalgia, chronic fatigue, and pain ...
Felix Royo, Hector Tames, Guillermo Bordanaba-Florit, Diana Cabrera, Maria Azparren-Angulo, Clara Garcia-Vallicrosa, Abelardo Margolles, Lorena Ruiz, Patricia Ruas-Madiedo, Juan M. Falcon-Perez   +9 more
doaj   +1 more source

Extracellular vesicles in idiopathic pulmonary fibrosis: pathogenesis and therapeutics

Inflammation and Regeneration, 2022
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease that occurs due to increased fibrosis of lung tissue in response to chronic injury of the epithelium.
Yu Fujita
doaj   +1 more source

Simultaneous Quantification of Steroid Hormones Using hrLC-MS in Endocrine Tissues of Male Rats and Human Samples

Metabolites, 2022
Steroid hormones play a vital role in the regulation of cellular processes, and dysregulation of these metabolites can provoke or aggravate pathological issues, such as autoimmune diseases and cancer.
Guillermo Bordanaba-Florit, Sebastiaan van Liempd, Diana Cabrera, Félix Royo, Juan Manuel Falcón-Pérez   +4 more
doaj   +1 more source

Extracellular Vesicles From Gastric Cancer Cells Induce PD-L1 Expression on Neutrophils to Suppress T-Cell Immunity

Frontiers in Oncology, 2020
Neutrophils are prominent components of solid tumors and exhibit distinct phenotypes in different tumor milieu. We have previously shown that tumor extracellular vesicles (EVs) could induce pro-tumor activation of neutrophils; however, the role of tumor ...
Yinghong Shi, Yinghong Shi, Jiahui Zhang, Jiahui Zhang, Zheying Mao, Zheying Mao, Han Jiang, Han Jiang, Wei Liu, Wei Liu, Hui Shi, Hui Shi, Runbi Ji, Runbi Ji, Wenrong Xu, Wenrong Xu, Hui Qian, Hui Qian, Xu Zhang, Xu Zhang   +19 more
doaj   +1 more source

Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells [PDF]

, 2019
BACKGROUND: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hypothesized that plasma exosomes,
Chen, Yanmin, Holmes, Lucy, Hu, Zihua, Jarvis, James N., Jiang, Kaiyu, Karasawa, Rie, O’Neil, Kathleen M.   +6 more
core   +1 more source