Results 41 to 50 of about 110,782 (262)
Frontiers in Bioengineering and BiotechnologyArtesunate (ATS) is considered the most widely employed artemisnin derivative in the treatment of Plasmodium falciparum malaria. However, poor solubility and low bioavailability of ATS limit its further clinical application.
Da Wang +12 more
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Cells, 2020 Research on extracellular vesicles (EVs) is growing exponentially due to an increasing appreciation of EVs as disease biomarkers and therapeutics, an expanding number of EV-containing materials under study, and application of new preparation, detection ...
Felix Royo +4 more
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Glioblastoma-Derived Exosomes as Nanopharmaceutics for Improved Glioma Treatment
Pharmaceutics, 2022 The use of cancer-derived exosomes has been studied in several cancer types, but the cancer-targeting efficacy of glioma-derived exosomes has not been investigated in depth for malignant glioblastoma (GBM) cells. In this study, exosomes were derived from
Hyeji Lee +7 more
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Exosomes and exosomal miRNAs in cardiovascular protection and repair [PDF]
Vascular Pharmacology, 2015 Cell-cell communication between cardiac and vascular cells and from stem and progenitor cells to differentiated cardiovascular cells is both an important and complex process, achieved through a diversity of mechanisms that have an impact on cardiovascular biology, disease and therapeutics.
Emanueli, Costanza +3 more
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Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness [PDF]
Journal of Extracellular Vesicles, 2015 Background: Exosomes have been implicated in tumour progression and metastatic spread. Little is known of the effect of mechanical and innate immune interactions of malignant cell-derived exosomes on endothelial integrity, which may relate to increased ...
Bradley Whitehead +8 more
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The RNA exosome and RNA exosome-linked disease [PDF]
RNA, 2017 The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes encoding both structural subunits of the RNA exosome and its cofactors have been
Derrick J. Morton +5 more
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Sensors, 2022 Dielectrophoresis (DEP) refers to a type of electrical motion of dielectric particles. Because DEP is caused by particle polarization, it has been utilized to characterize particles.
Hao Chen +4 more
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Assessment of bovine milk exosome preparation and lyophilized powder stability
Journal of Extracellular BiologyExosomes are cell‐derived nanovesicles that play a crucial role in intercellular communication, presenting promising potential as biomarkers and therapeutic agents.
Lu Lu +12 more
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Frontiers in Bioengineering and Biotechnology, 2023 Mesenchymal stem cells (MSCs), one of the most common types of stem cells, are involved in the modulation of the tumor microenvironment (TME). With the advancement of nanotechnology, exosomes, especially exosomes secreted by MSCs, have been found to play
You Zhou +4 more
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source