Results 21 to 30 of about 147,911 (307)

Exosomes

Annual Review of Biochemistry, 2019
Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are ...
Pegtel, D. Michiel, Gould, Stephen J.
openaire   +2 more sources

Exosomes are natural carriers of exogenous siRNA to human cells in vitro [PDF]

, 2013
© 2013 Shtam et al. Background: Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA.
Varfolomeeva, EY, Kovalev, RA, Makarov, EM, Kil, YV, Filatov, MV, Shtam, TA, Elena Varfolomeeva, Roman A Kovalev, Tatyana A Shtam, Michael V Filatov, Evgeny M Makarov, Yury V Kil   +11 more
core   +1 more source

Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

Cells, 2020
Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials ...
Lei Yin, Xiaotian Liu, Yinghong Shi, Dickson Kofi Wiredu Ocansey, Yuyan Hu, Xiaoxi Li, Chenxiao Zhang, Wenrong Xu, Hui Qian   +8 more
doaj   +1 more source

Urinary Exosomes [PDF]

The Scientific World JOURNAL, 2009
Exosomes are nanovesicles of endocytic origin that are secreted into the extracellular space or body fluids when a multivesicular body (MVB) fuses with the cell membrane. Interest in exosomes intensified after their description in antigen-presenting cells and the observation that they can significantly moderate immune responsesin vivo.
Irena Dimov, Ljubinka Jankovic Velickovic, Vladisav Stefanovic   +2 more
openaire   +3 more sources

Human urinary exosomes in bladder cancer patients : properties, concentrations and possible clinical application [PDF]

, 2015
OBJECTIVE: High grade bladder cancer is extremely aggressive. Early detection is thus an important challenge. De- velopment of non-invasive diagnostic tools particularly using urine samples could be of importance in the diagnosis and surveillance of ...
Mullen, Peter, Chapman, Alex, Hacker, Christian, Leung, Steve, Lucocq, John Milton, Bowness, James Simeon, McLornan, Liz, Cameron, Ruth, Harrison, David James, Powis, Simon John, Chinn, David John, Riches, Andrew Clive, Harrison, David James; id_orcid, Powis, Simon John; id_orcid, Mullen, Peter; id_orcid, Bowness, James Simeon; id_orcid   +15 more
core   +1 more source

Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles

Cells, 2021
Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs.
Diana Sousa, Raquel T. Lima, Vanessa Lopes-Rodrigues, Esperanza Gonzalez, Félix Royo, Cristina P. R. Xavier, Juan M. Falcón-Pérez, M. Helena Vasconcelos   +7 more
doaj   +1 more source

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]

, 2013
Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Szabó, Tamas G, Szabó, Tamás G., Buzás, Edit Irén, Lötvall, Jan, Jan Lötvall, Lässer, Cecilia, Dianzani, Irma, Irma Dianzani, Edit I. Buzás, Jan Lötvall, Buzás, Edit I, Maria Eldh, Crescitelli, Rossella, Kittel, Ágnes, Eldh, Maria, Rossella Crescitelli, Agnes Kittel, Tamas G. Szabó, Edit I. Buzás, Cecilia Lässer, Tamas G. Szabó, Cecilia Lässer, Eldh, Maria,, Lässer, Cecilia,, Lötvall, Jan,, Crescitelli, Rossella,   +25 more
core   +1 more source

Tuberous Sclerosis Complex cell‐derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers

Journal of Extracellular Vesicles, 2023
Hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) is a feature of many solid tumours and is a key pathogenic driver in the inherited condition Tuberous Sclerosis Complex (TSC).
Muireann Ní Bhaoighill, Juan M. Falcón‐Pérez, Félix Royo, Andrew R. Tee, Jason P. Webber, Elaine A. Dunlop   +5 more
doaj   +1 more source

Exosomes in the gut [PDF]

Frontiers in Immunology, 2014
Recent studies have highlighted the importance of cross-talk between our immune systems and our gut microbiota, the complex community of over 100 trillion commensal microorganisms (bacteria, archaea, fungi, and protozoans) that resides in the human gastrointestinal tract and which numbers about 10 times the total cells in the human body (1).
Smythies, Lesley E., Smythies, John R.
openaire   +3 more sources

GelMA‐Based Hydrogel Encapsulating Astragalus Polysaccharides and Umbilical Cord Mesenchymal Stem Cell Exosomes Promotes Full‐Thickness Skin Wound Healing [PDF]

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Wound healing involves excessive oxidative stress and cellular dysfunction, while current single therapies remain inadequate. Astragalus polysaccharides (APS) and exosomes (Exos) possess antioxidative and regenerative properties, and gelatin methacryloyl (GelMA) hydrogel provides a biocompatible platform for localized delivery. Here,
Jingwen Tian, Xiangjing Zhao, Jingxian Xie, Zheng Huang, Pengbo Song, Suzhuang Hong, Cailing Tong, Zhongquan Qi   +7 more
wiley   +2 more sources