Results 31 to 40 of about 147,911 (307)
The EMBO Reports, 2007 The correct processing, quality control and turnover of cellular RNA molecules is crucial to many aspects of cell physiology. The exosome—a large molecular assembly with exoribonuclease activity—has emerged as a crucial component in many, if not most, stages of RNA metabolism, including degradation and maturation of ribosomal RNA, RNA quality control ...
Hartung, Sophia, Hopfner, Karl-Peter
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, 2022 Exosomes participate in the progression and angiogenesis of esophageal squamous cell carcinoma (ESCC). This study aimed to explore the effect and mechanism of exosomes-derived miR-154-5p on the progression and angiogenesis of ESCC.
Yinghao Liang (12084245) +4 more
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Hepatology Communications, 2018 Drug‐induced liver injury (DILI) is a serious worldwide health problem that accounts for more than 50% of acute liver failure. There is a great interest in clinical diagnosis and pharmaceutical industry to elucidate underlying molecular mechanisms and ...
Laura Palomo +7 more
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Stem Cell Research & Therapy, 2022 Background Mesenchymal stromal cells (MSCs) and their extracellular vesicles (MSC-EVs) have demonstrated to elicit immunomodulatory and pro-regenerative properties that are beneficial for the treatment of chronic wounds.
Kevin Las Heras +6 more
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Annals of Hepatology, 2021 Introduction: Alcohol abuse has a high impact on the mortality and morbidity related to a great number of diseases and is responsible for the development of alcoholic liver disease (ALD).
E. Gonzalez +6 more
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Development of whole body scanning PCR, a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides [PDF]
, 2015 Based on RNA interference (RNAi), a mechanism regulating gene expression at the post-transcriptional level in eukaryotes, therapeutic siRNAs are slowly moving towards late phase clinical trials.
Boos, Julien Alfred Jean-Paul
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Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients [PDF]
, 2013 Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted, exosomes are able to attach to recipient cells and release miRNAs potentially modulating the function of the recipient cell.
Andrea Schmitt +49 more
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Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
Genomics, Proteomics & Bioinformatics, 2015 Abstract Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently, mRNAs and microRNAs (miRNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate ...
Jian Zhang 0017 +6 more
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Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis
Gastroenterology Research and Practice, 2021 Circular RNA CDR1as has been demonstrated to participate in various cancer progressions as miRNA sponges. The exact underlying mechanisms of CDR1as on gastric cancer (GC) metastasis remain unknown. Here, we found that CDR1as knockdown facilitated GC cell
Jiajia Jiang +5 more
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Role of Exosomes and Exosomal microRNAs in Cancer
Future Science OA, 2020 A growing body of evidence indicates that exosomes play a critical role in the cell-cell communication process. Exosomes are biological nanoparticles with an average diameter of 30-100 nm in size and are produced by almost all cell types in the human body; however, cancer cells contain higher concentrations of exosomes than healthy cells.
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