Results 21 to 30 of about 12,399 (169)
Organization of NMDA receptors at extrasynaptic locations [PDF]
Neuroscience, 2010 NMDA receptors are found in neurons both at synapses and in extrasynaptic locations. Extrasynaptic locations are poorly characterized. Here we used preembedding immunoperoxidase and postembedding immunogold electron microscopy and fluorescence light microscopy to characterize extrasynaptic NMDA receptor locations in dissociated hippocampal neurons in ...
R S, Petralia +7 more
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Imaging extrasynaptic glutamate dynamics in the brain [PDF]
Proceedings of the National Academy of Sciences, 2009 Glutamate is the major neurotransmitter in the brain, mediating point-to-point transmission across the synaptic cleft in excitatory synapses. Using a glutamate imaging method with fluorescent indicators, we show that synaptic activity generates extrasynaptic glutamate dynamics in the vicinity of active synapses.
Yohei, Okubo +8 more
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Frontiers in Cellular Neuroscience, 2015 Despite numerous advances, treatment-resistant seizures remain an important problem. Loss of neuronal inhibition is present in a variety of epilepsy models and is suggested as a mechanism for increased excitability, leading to the proposal that grafting ...
Manoj K. Jaiswal +9 more
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BMC Neuroscience, 2008 Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar +2 more
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Cerebellar Cortex: Computation by Extrasynaptic Inhibition? [PDF]
Current Biology, 2002 In the cerebellar cortex, inhibitory inputs to granule cells exhibit prominent tonic and spillover components resulting from the activation of extrasynaptic receptors. A recent study shows how extrasynaptic inhibition affects information flow through cerebellar cortex.
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Extrasynaptic NMDA Receptor in Excitotoxicity [PDF]
The Neuroscientist, 2014 It is generally accepted that proper activation of N-methyl-d-aspartate receptors (NMDARs) promotes neuronal survival and supports neuroplasticity, and excessive NMDAR activation leads to pathological outcomes and neurodegeneration. As NMDARs are found at both synaptic and extrasynaptic sites, there is significant interest in determining how NMDARs at ...
Xianju, Zhou +5 more
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Glutamate-Mediated Extrasynaptic Inhibition [PDF]
Neuron, 2001 Abstract NMDA receptors (NMDARs) typically contribute to excitatory synaptic transmission in the CNS. While Ca 2+ influx through NMDARs plays a critical role in synaptic plasticity, direct actions of NMDAR-mediated Ca 2+ influx on neuronal excitability have not been well established. Here we show that Ca 2+ influx through NMDARs is directly coupled
Isaacson, Jeffry S., Murphy, Gabe J.
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Astrocytic Actions on Extrasynaptic Neuronal Currents [PDF]
Frontiers in Cellular Neuroscience, 2015 In the last few decades, knowledge about astrocytic functions has significantly increased. It was demonstrated that astrocytes are not passive elements of the central nervous system (CNS), but active partners of neurons. There is a growing body of knowledge about the calcium excitability of astrocytes, the actions of different gliotransmitters and ...
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Extracellular space diffusion and extrasynaptic transmission
Physiological Research, 2008 The diffusion of neuroactive substances in the extracellular space (ECS) plays an important role in short- and long-distance communication between nerve cells and is the underlying mechanism of extrasynaptic (volume) transmission. The diffusion properties of the ECS are described by three parameters: 1. ECS volume fraction alpha (alpha=ECS volume/total
L, Vargová, E, Syková
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Oligomerization and cell surface expression of recombinant GABAA receptors tagged in the δ subunit
Journal of Integrative Neuroscience, 2019 The γ-Aminobutyric acid type A receptors (GABAARs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain.
Furkan Enes Oflaz +2 more
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