Results 21 to 30 of about 14,388 (200)

Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites [PDF]

The EMBO Journal
Neurotransmitter receptors are critical for neuronal communication. They often form large multimeric complexes that differ in their subunit composition, distribution, and signaling properties. N‐methyl‐D‐aspartate receptors (NMDARs), a class of glutamate-
Antoine Sicard, Meilin Tian, Zakaria Mostefai, Sophie Shi, Cécile Cardoso, Joseph Zamith, Isabelle McCort-Tranchepain, Cécile Charrier, Pierre Paoletti, Laetitia Mony   +9 more
doaj   +2 more sources

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats

The Journal of Headache and Pain
Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors.
Berkay Alpay, Bariscan Cimen, Elif Akaydin, Filiz Onat, Hayrunnisa Bolay, Yildirim Sara   +5 more
doaj   +2 more sources

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments. [PDF]

Pharmacol Res Perspect
ABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Okada M, Okubo R, Oka T, Motomura E.
europepmc   +2 more sources

Organization, control and function of extrasynaptic NMDA receptors [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2014
International audienceN-methyl D-aspartate receptors (NMDARs) exist in different forms owing to multiple combinations of subunits that can assemble into a functional receptor.
Papouin, Thomas, Oliet, Stéphane, H.R.
core   +4 more sources

Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis

Biomedicines, 2023
(1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response.
Aleksandar R. Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A. Weigand, Sebastian O. Decker   +5 more
doaj   +1 more source

Contributions of Astrocyte and Neuronal Volume to CA1 Neuron Excitability Changes in Elevated Extracellular Potassium

Frontiers in Cellular Neuroscience, 2022
Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch, Erin Walch, Alexander Bilas, Alexander Bilas, Valine Bebawy, Angelina Lam, Thomas R. Murphy, Thomas R. Murphy, Sandhya Sriram, Sandhya Sriram, Todd A. Fiacco, Todd A. Fiacco, Todd A. Fiacco   +12 more
doaj   +1 more source

Regulating anxiety with extrasynaptic inhibition [PDF]

Nature Neuroscience, 2015
Aversive experiences can lead to complex behavioral adaptations including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes, however, are poorly understood. Here, using a combination of behavioral, physiological and optogenetic approaches in mouse, we identify a specific ...
Botta P., Demmou L., Kasugai Y., Markovic M., Xu C., Fadok J. P., Lu T., Poe M. M., Xu L., Cook J. M., Rudolph U., Sah P., Ferraguti F., Luthi A.   +13 more
openaire   +7 more sources

Extrasynaptic neuron-glia communication [PDF]

Communicative & Integrative Biology, 2011
Chemical synaptic transmission between neurons is believed to take place at specialized sites of cell contact, comprising presynaptic terminals and postsynaptic membranes. Neurotransmitter release has been shown to occur also extrasynaptically, mainly targeting glial cells. In a recent study, we investigated the mechanism of extrasynaptic glutamate and
Christian, Lohr, Anne, Thyssen, Daniela, Hirnet   +2 more
openaire   +2 more sources

Extrasynaptic and postsynaptic receptors in glycinergic and GABAergic neurotransmission: a division of labor?

Frontiers in Molecular Neuroscience, 2008
Glycine and GABA mediate inhibitory neurotransmission in the spinal cord and central nervous system. The general concept of neurotransmission is now challenged by the contribution of both phasic activation of postsynaptic glycine and GABAA receptors ...
Emilie Muller, Emilie Muller, Hervé Le-Corronc, Pascal Legendre   +3 more
doaj   +1 more source

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B., Lambert, Jeremy J., Delia Belelli, Jeremy J. Lambert, Belelli, Delia, Murray B. Herd   +5 more
core   +1 more source