Results 21 to 30 of about 15,145 (185)

Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks [PDF]

Frontiers in Physiology, 2012
Extrasynaptic neurotransmission is an important short distance form of volume transmission (VT) and describes the extracellular diffusion of transmitters and modulators after synaptic spillover or extrasynaptic release in the local circuit regions ...
Kjell eFuxe, Dasiel Oscar Borroto-Escuela, Wilber eRomero-Fernandez, Zaida eDiaz Cabiale, Alicia eRivera, Luca eFerraro, Sergio eTanganelli, Alexander O Tarakanov, Pere eGarriga, Jose A. eNarvaez, Francisco eCiruela, Luigi F Agnati   +11 more
doaj   +4 more sources

GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus [PDF]

Frontiers in Cellular Neuroscience
Glucagon-like peptide-1 (GLP-1) is a metabolic hormone secreted by L-cells in the gut and it stimulates insulin secretion in the pancreatic islets by activating GLP-1 receptors (GLP-1Rs).
Olga Netsyk, Sergiy V. Korol, Bryndis Birnir, Zhe Jin   +3 more
doaj   +2 more sources

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats

The Journal of Headache and Pain
Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors.
Berkay Alpay, Bariscan Cimen, Elif Akaydin, Filiz Onat, Hayrunnisa Bolay, Yildirim Sara   +5 more
doaj   +2 more sources

Regulating anxiety with extrasynaptic inhibition [PDF]

Nature Neuroscience, 2015
Aversive experiences can lead to complex behavioral adaptations including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes, however, are poorly understood. Here, using a combination of behavioral, physiological and optogenetic approaches in mouse, we identify a specific ...
Botta P., Demmou L., Kasugai Y., Markovic M., Xu C., Fadok J. P., Lu T., Poe M. M., Xu L., Cook J. M., Rudolph U., Sah P., Ferraguti F., Luthi A.   +13 more
openaire   +7 more sources

Extrasynaptic neuron-glia communication [PDF]

Communicative & Integrative Biology, 2011
Chemical synaptic transmission between neurons is believed to take place at specialized sites of cell contact, comprising presynaptic terminals and postsynaptic membranes. Neurotransmitter release has been shown to occur also extrasynaptically, mainly targeting glial cells. In a recent study, we investigated the mechanism of extrasynaptic glutamate and
Christian, Lohr, Anne, Thyssen, Daniela, Hirnet   +2 more
openaire   +2 more sources

Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors. [PDF]

, 2022
Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ- and π-subunits1. αβ, α4βδ, α6βδ and α5βγ receptors favour extrasynaptic localization, and
Smart, Trevor G, Mortensen, Martin, Hardwick, Steven W, Kasaragod, Vikram Babu, Chirgadze, Dimitri Y, Wahid, Ayla A, Miller, Paul S, Dorovykh, Valentina   +7 more
core   +13 more sources

Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. [PDF]

, 2015
GABAA receptors are important for inhibition in the CNS where neurosteroids and protein kinases are potent endogenous modulators. Acting individually, these can either enhance or depress receptor function, dependent upon the type of neurosteroid or ...
Adams, JM, Thomas, P, Adams, Joanna M., Thomas, Philip, Smart, Trevor G., Smart, TG   +5 more
core   +1 more source

Organization of NMDA receptors at extrasynaptic locations [PDF]

Neuroscience, 2010
NMDA receptors are found in neurons both at synapses and in extrasynaptic locations. Extrasynaptic locations are poorly characterized. Here we used preembedding immunoperoxidase and postembedding immunogold electron microscopy and fluorescence light microscopy to characterize extrasynaptic NMDA receptor locations in dissociated hippocampal neurons in ...
R S, Petralia, Y X, Wang, F, Hua, Z, Yi, A, Zhou, L, Ge, F A, Stephenson, R J, Wenthold   +7 more
openaire   +2 more sources

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B., Lambert, Jeremy J., Delia Belelli, Jeremy J. Lambert, Belelli, Delia, Murray B. Herd   +5 more
core   +1 more source

Imaging extrasynaptic glutamate dynamics in the brain [PDF]

Proceedings of the National Academy of Sciences, 2009
Glutamate is the major neurotransmitter in the brain, mediating point-to-point transmission across the synaptic cleft in excitatory synapses. Using a glutamate imaging method with fluorescent indicators, we show that synaptic activity generates extrasynaptic glutamate dynamics in the vicinity of active synapses.
Yohei, Okubo, Hiroshi, Sekiya, Shigeyuki, Namiki, Hirokazu, Sakamoto, Sho, Iinuma, Miwako, Yamasaki, Masahiko, Watanabe, Kenzo, Hirose, Masamitsu, Iino   +8 more
openaire   +2 more sources