Results 1 to 10 of about 1,325 (113)

The GABAA Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice

Frontiers in Immunology, 2021
BackgroundMyocardial macrophages have key roles in cardiac remodeling and dysfunction. The gamma-aminobutyric acid subtype A (GABAA) receptor was recently found to be distributed in macrophages, allowing regulation of inflammatory responses to various ...
Jin Bu, Shiyuan Huang, Jue Wang, Tong Xia, Hui Liu, Ya You, Zhaohui Wang, Kun Liu   +7 more
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Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients. [PDF]

PLoS ONE, 2015
Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability.
Charlotte D'Hulst, Inge Heulens, Nathalie Van der Aa, Karolien Goffin, Michel Koole, Kathleen Porke, Marc Van De Velde, Liesbeth Rooms, Wim Van Paesschen, Hilde Van Esch, Koen Van Laere, R Frank Kooy   +11 more
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Altered GABAA receptor function in women with endometriosis: a possible pain‐related mechanism

Acta Obstetricia et Gynecologica Scandinavica, 2023
Introduction The mechanism underlying endometriosis‐related pain remains poorly understood. Previous studies have indicated that γ‐aminobutyric acid (GABA) type A (GABAA) receptors and GABAergic substances (eg endogenous neurosteroids) play important ...
Anton Sandström, Marie Bixo, Torbjörn Bäckström, Anna Möller, Sahruh Turkmen   +4 more
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Characterization of zebrafish GABAA receptor subunits

Scientific Reports, 2021
γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, exerts its effect through the activation of GABA receptors. GABAA receptors are ligand-gated chloride channels composed of five subunit proteins.
Kenichiro Sadamitsu, Leona Shigemitsu, Marina Suzuki, Daishi Ito, Makoto Kashima, Hiromi Hirata   +5 more
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Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAA and GABAB receptors

Reproductive Medicine and Biology, 2023
Purpose Several widely used substances (e.g., some therapeutics or food supplements) can act on gamma‐aminobutyric acid (GABA) receptors, and we investigated whether the activation of these receptors could affect the preimplantation embryo.
Veronika Kovaříková, Alexandra Špirková, Zuzana Šefčíková, Jozef Pisko, Laura Kalatová, Juraj Koppel, Dušan Fabian, Štefan Čikoš   +7 more
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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

Scientific Reports, 2021
GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders.
Joerg F. Hipp, Frederic Knoflach, Robert Comley, Theresa M. Ballard, Michael Honer, Gerhard Trube, Rodolfo Gasser, Eric Prinssen, Tanya L. Wallace, Andreas Rothfuss, Henner Knust, Sian Lennon-Chrimes, Michael Derks, Darren Bentley, Lisa Squassante, Stephane Nave, Jana Nöldeke, Christoph Wandel, Andrew W. Thomas, Maria-Clemencia Hernandez   +19 more
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Neurosteroids and GABA-A receptor function

Frontiers in Endocrinology, 2011
Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals and the gonads and have potent and selective effects on the GABAA-receptor.
Mingde eWang
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Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
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PKCε and Allopregnanolone: functional cross-talk at the GABAA receptor level

Frontiers in Cellular Neuroscience, 2015
Changes in GABAergic inhibition occur during physiological processes, during response to drugs and in various pathologies. These changes can be achieved through direct allosteric modifications at the γ-aminobutyric (GABA) type A (GABAA) receptor protein ...
Giulia ePuja, Federica eRavazzini, Luca Franco Castelnovo, Valerio eMagnaghi   +3 more
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Role of allopregnanolone-mediated γ-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: Toward precise targets for translational medicine and drug development

Frontiers in Psychiatry, 2023
Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress ...
Qian Gao, Qian Gao, Qian Gao, Wei Sun, Wei Sun, Yue-Rui Wang, Yue-Rui Wang, Yue-Rui Wang, Zi-Fa Li, Zi-Fa Li, Feng Zhao, Feng Zhao, Xi-Wen Geng, Xi-Wen Geng, Xi-Wen Geng, Kai-Yong Xu, Dan Chen, Kun Liu, Kun Liu, Kun Liu, Ying Xing, Ying Xing, Ying Xing, Wei Liu, Sheng Wei, Sheng Wei, Sheng Wei   +26 more
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