Results 11 to 20 of about 1,283,132 (206)

Efectos de los pesticidas organoclorados sobre la neurotransmisión glutamatérgica en cultivos primarios neuronales. Interacciones con el sistema neuroendocrino. [PDF]

, 2011
Los pesticidas organoclorados (POCs) son compuestos altamente persistentes en el medio ambiente y dada su capacidad de acumularse en los tejidos grasos animales se biomagnifican a lo largo de la cadena trófica.
Briz Herrezuelo, Victor
core   +6 more sources

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
Topf, Maya, Hannan, S, Topf, M, Smart, T.G., Baker, JR, Iqbal, F, Iqbal, F., Baker, J.R., Hannan, S., Mortensen, M, Huckvale, R, Pandurangan, Arun, Pandurangan, AP, Huckvale, R., Mortensen, M., Smart, TG   +15 more
core   +1 more source

Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. [PDF]

, 2015
GABAA receptors are important for inhibition in the CNS where neurosteroids and protein kinases are potent endogenous modulators. Acting individually, these can either enhance or depress receptor function, dependent upon the type of neurosteroid or ...
Adams, JM, Thomas, P, Adams, Joanna M., Thomas, Philip, Smart, Trevor G., Smart, TG   +5 more
core   +1 more source

PKCε and Allopregnanolone: functional cross-talk at the GABAA receptor level

Frontiers in Cellular Neuroscience, 2015
Changes in GABAergic inhibition occur during physiological processes, during response to drugs and in various pathologies. These changes can be achieved through direct allosteric modifications at the γ-aminobutyric (GABA) type A (GABAA) receptor protein ...
Giulia ePuja, Federica eRavazzini, Luca Franco Castelnovo, Valerio eMagnaghi   +3 more
doaj   +1 more source

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]

, 2013
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B, Belelli, D., Wlodarczyk, A. I., Sylantyev, S., Linthorst, Astrid C.E., Walker, Matthew C., Walker, M. C., Rusakov, Dmitri A, Lambert, Jeremy J, Wlodarczyk, Agnieszka I., Kersanté, Flavie, Walker, Matthew C, Semyanov, A., Semyanov, Alexey, Rusakov, Dmitri A., Rusakov, D. A., Herd, Murray B., Linthorst, A. C. E., Lambert, Jeremy J., Pavlov, I., Linthorst, Astrid C E, Lambert, J. J., Herd, M. B., Kersante, F., Wlodarczyk, Agnieszka I, Pavlov, Ivan, Sylantyev, Sergiy, Belelli, Delia   +27 more
core   +1 more source

PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
Guang Yang, Wen-Hao Dong, Chang-Long Hu, Yan-Ai Mei   +3 more
doaj   +1 more source

Role of allopregnanolone-mediated γ-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: Toward precise targets for translational medicine and drug development

Frontiers in Psychiatry, 2023
Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress ...
Qian Gao, Qian Gao, Qian Gao, Wei Sun, Wei Sun, Yue-Rui Wang, Yue-Rui Wang, Yue-Rui Wang, Zi-Fa Li, Zi-Fa Li, Feng Zhao, Feng Zhao, Xi-Wen Geng, Xi-Wen Geng, Xi-Wen Geng, Kai-Yong Xu, Dan Chen, Kun Liu, Kun Liu, Kun Liu, Ying Xing, Ying Xing, Ying Xing, Wei Liu, Sheng Wei, Sheng Wei, Sheng Wei   +26 more
doaj   +1 more source

Ethnomedicine-based discovery and characterization of plant-derived GABAΑ receptor modulators with new scaffolds [PDF]

, 2014
Inhibitory neurotransmission in the central nervous system (CNS) largely relies on the actions of gamma aminobutyric acid (GABA) on GABAA receptors, heteropentameric ligand-gated chloride channels assembled from 19 possible subunits (α1-6, β1-3, γ1-3, δ,
Rueda, Diana Carolina
core   +1 more source

Regulation of GABAA-Receptor Surface Expression With Special Reference to the Involvement of GABARAP (GABAA Receptor-Associated Protein) and PRIP (Phospholipase C-Related, but Catalytically Inactive Protein)

Journal of Pharmacological Sciences, 2007
GABAA receptors are heteropentameric ligand-gated chloride channels composed of a variety of subunits, including α1 – 6, β1 – 3, γ1 – 3, δ, ε, θ, and π, and play a key role in controlling inhibitory neuronal activity.
Takashi Kanematsu, Akiko Mizokami, Keiko Watanabe, Masato Hirata   +3 more
doaj   +1 more source

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

eLife, 2018
Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors.
Swastik Phulera, Hongtao Zhu, Jie Yu, Derek P Claxton, Nate Yoder, Craig Yoshioka, Eric Gouaux   +6 more
doaj   +1 more source