Results 41 to 50 of about 1,283,132 (206)

Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]

, 2005
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Walker, M.C., Sperk, G., Scimemi, A., Semyanov, A., Kullmann, D.M.   +4 more
core  

Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]

, 2011
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Errington, Adam C., Di Giovanni, Giuseppe, Crunelli, Vincenzo   +2 more
core  

Steady‐state activation and modulation of the synaptic‐type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands

Physiological Reports, 2019
The synaptic α1β2γ2 GABAA receptor is activated phasically by presynaptically released GABA. The receptor is considered to be inactive between synaptic events when exposed to ambient GABA because of its low resting affinity to the transmitter.
Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Ariel B. Burbridge, Joe Henry Steinbach, Gustav Akk   +5 more
doaj   +1 more source

GABAA Receptor Subunit Transcriptional Regulation, Expression Organization, and Mediated Calmodulin Signaling in Prefrontal Cortex of Rats Showing Testosterone-Mediated Impulsive Behavior

Frontiers in Neuroscience, 2020
Testosterone can induce impulsivity, a behavioral impairment associated with various psychiatric illnesses. The molecular mechanisms associated with testosterone-induced impulsivity are unclear. Our earlier studies showed that supraphysiological doses of
Juhee Agrawal, Yogesh Dwivedi
doaj   +1 more source

GABAA receptor subtypes and benzodiazepine use, misuse, and abuse

Frontiers in Psychiatry, 2023
Benzodiazepines have been in use for over half a century. While they remain highly prescribed, their unfavorable side-effect profile and abuse liability motivated a search for alternatives.
Elif Engin, Elif Engin
doaj   +1 more source

Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol [PDF]

, 2014
BACKGROUND Magnolia bark preparations from Magnolia officinalis of Asian medicinal systems are known for their muscle relaxant effect and anticonvulsant activity.
Sigel, Erwin, Schuehly, Wolfgang, Baur, Roland   +2 more
core   +1 more source

γ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors. [PDF]

PLoS ONE, 2013
γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABAB receptors with millimolar affinity, but also binds with much higher affinity to another site ...
William M Connelly, Adam C Errington, Vincenzo Crunelli   +2 more
doaj   +1 more source

Investigating the interplay between excitatory neurotransmission and GABAa receptor expression and trafficking in the stargazer mutant mouse [PDF]

, 2006
The stargazer mutant mouse is an animal model of human absence epilepsy and cerebellar ataxia. The stargazer mutation results in the complete ablation of expression of TARPy2， an AMPA receptor (AMPAR) auxiliary subunit.
Payne, Helen Louise
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Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors [PDF]

, 2002
GABA(A) receptors are the principal sites of fast synaptic inhibition in the brain. These receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta, and pi, but the ...
Trevor G Smart, Brandon, NJ, Jovanovic, JN, Moss, SJ, Stephen J Moss, Smart, TG, Nicholas J Brandon, Jasmina N Jovanovic   +7 more
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Removal of GABA(A) Receptor gamma 2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations [PDF]

, 2011
Peer ...
Sieghart Werner, Esko Toppila, Swinny, Jerome, Höger Harald, Wisden, William, Swinny Jerome D., Korpi, Esa R., Hoeger, Harald, Wulff, P., Leppa, E., Wisden, W., Ville Rantanen, Hoger, H., Rantanen Ville, Korpi, E., Swinny, Jerome D., Wulff Peer, Toppila, E., Rantanen, Ville, Jerome D. Swinny, Vekovischeva, Olga Y., Werner Sieghart, Sieghart, Werner, Vekovischeva, O., Elli Leppä, Vekovischeva Olga Y., Korpi Esa R., Sieghart, W., Olga Y. Vekovischeva, Toppila Esko, Leppä Elli, Olga Y Vekovischeva, Esa R Korpi, Linden, Anni-Maija, Rantanen, V., Jerome D Swinny, Linden Anni-Maija, Toppila, Esko, Anni-Maija Linden, Linden, A., Harald Höger, Wisden William, Leppä, Elli, William Wisden, Peer Wulff, Wulff, Peer, Esa R. Korpi   +46 more
core   +2 more sources