GABA(B) receptor-mediated modulation of synaptic plasticity in the lateral amygdala [PDF]
, 2005 Fear conditioning, one of the most powerful and widely used methods to investigate the mechanisms of associative learning in animals, involves the pairing of an aversive stimulus such as a foot-shock (the unconditioned stimulus; US) with a neutral ...
Shaban, Hamdy
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Probing novel compound classes & a new interacting protein for the Mammalian GАВА(_A) receptor [PDF]
, 2006 y-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate brain mediating its fast inhibitory action via GABA(_A) receptors. These receptors are implicated in a number of neurological diseases, making GABA(_A) receptor ligands
Abuhamdah, Sawsan "Mohammad Ali"
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Loop B is a major structural component of the 5-HT3 receptor [PDF]
, 2008 The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
Thompson, Andrew J. +9 more
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Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]
, 2014 Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole +16 more
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Molecular Brain, 2017 GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on the brain and behavior. One-dose ethanol exposure induces transient plastic changes in GABAA receptor subunit levels, composition, and regional and subcellular ...
Richard W. Olsen, Jing Liang
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An electrophysiological study of the interaction between fenamate NSAIDs and the GABA(_A) receptor [PDF]
, 1999 The effects of certain NSAIDs were determined on agonist-evoked responses recorded from rat neurones maintained in vitro using electrophysiological techniques. Initially, the rat isolated vagus and optic nerves were employed. Alphaxalone, pentobarbitone,
Patten, Debra
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Modulation of ion channels by natural products - identification of hERG channel inhibitors and GABAA receptor ligands from plant extracts [PDF]
, 2014 Ion channels are expressed in virtually all cell types in the human body and are involved in various physiological processes. Hence, it is not surprising that ion channels play an important role in modern drug discovery.
Schramm, Anja
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Agarwood Essential Oil Displays Sedative-Hypnotic Effects through the GABAergic System
Molecules, 2017 Although agarwood has been used as a tranquilizer in Asian countries for hundreds of years, the underlying pharmacological basis is still unclear. This study investigated the sedative-hypnotic effect of agarwood essential oil (AEO) using locomotor ...
Shuai Wang +6 more
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Scientific ReportsContextual learning requires strengthening at both AMPA receptor-mediated excitatory synapses and GABAA receptor-mediated inhibitory synapses in CA1 neurons. However, the precise mechanisms underlying learning-induced strengthening at inhibitory synapses
Yuya Sakimoto +3 more
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Output of neurogliaform cells to various neuron types in the human and rat cerebral cortex
Frontiers in Neural Circuits, 2007 Neurogliaform cells in the rat elicit combined GABAA and GABAB receptor-mediated postsynaptic responses on cortical pyramidal cells and establish electrical synapses with various interneuron types.
Szabolcs Oláh +6 more
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