Results 1 to 10 of about 39,325 (214)
Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABAA Receptors in Dentate Granule Neurons
Frontiers in Molecular Neuroscience, 2020 GABAA receptors mediate a large fraction of inhibitory neurotransmission in the central nervous system. Two major classes of GABAA receptors are γ2-containing receptors and δ-containing receptors, which are largely located synaptically and ...
Xinguo Lu +2 more
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Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs [PDF]
Cell Reports, 2023 Summary: We describe a retrograde synaptic signal at the C. elegans GABAergic neuromuscular junction. At this synapse, GABA release is controlled by two voltage-activated calcium channels (UNC-2/CaV2 and EGL-19/CaV1), and muscle responses are mediated by
Jian Zhao +3 more
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Two Distinct Populations of α1α6-Containing GABAA-Receptors in Rat Cerebellum
Frontiers in Synaptic Neuroscience, 2020 GABAA receptors are pentameric GABA-gated chloride channels. The existence of 19 different subunits (six α, three β, three γ, δ, ε, θ, π, and three ρ) in mammalian systems gives rise to an enormous theoretical diversity of GABAA receptor subtypes with ...
Petra Scholze +2 more
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Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation. [PDF]
PLoS ONE, 2014 Acid-sensing ion channels (ASICs) belong to the family of the epithelial sodium channel/degenerin (ENaC/DEG) and are activated by extracellular protons. They are widely distributed within both the central and peripheral nervous systems.
Dongbo Zhao +6 more
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Cell & Bioscience, 2022 Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy.
Meng Wang +9 more
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Frontiers in Pharmacology, 2023 Zulresso (brexanolone) is an aqueous formulation of the neurosteroid, allopregnanolone, and the only FDA-approved medication for the treatment of postpartum depression (PPD).
Alexander B. Horwitz +2 more
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Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. [PDF]
PLoS ONE, 2018 GABA is a robust regulator of both developing and mature neural networks. It exerts many of its effects through GABAA receptors, which are heteropentamers assembled from a large array of subunits encoded by distinct genes.
Bryan Monesson-Olson +6 more
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Frontiers in Aging Neuroscience, 2022 Background: Perioperative neurocognitive disorders (PNDs) occur commonly in older patients after anesthesia and surgery. Treating astrocytes with general anesthetic drugs stimulates the release of soluble factors that increase the cell-surface expression
Woosuk Chung +7 more
doaj +1 more source
eLife, 2018 Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors.
Swastik Phulera +6 more
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GABAA Receptor Subunits in Rat Testis and Sperm [PDF]
International Journal of Fertility and Sterility, 2008 Background γ-Aminobutyric acid (GABA) is considered to be the predominant inhibitory neurotransmitter in mammalian central nervous systems (CNS). There are two major classes of GABA receptors: GABAARs and GABABRs.
Abolghasem Esmaeili
doaj +1 more source