Results 31 to 40 of about 582,495 (272)

Characterization of zebrafish GABAA receptor subunits

Scientific Reports, 2021
γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, exerts its effect through the activation of GABA receptors. GABAA receptors are ligand-gated chloride channels composed of five subunit proteins.
Kenichiro Sadamitsu, Leona Shigemitsu, Marina Suzuki, Daishi Ito, Makoto Kashima, Hiromi Hirata   +5 more
doaj   +1 more source

Ethnomedicine-based discovery and characterization of plant-derived GABAΑ receptor modulators with new scaffolds [PDF]

, 2014
Inhibitory neurotransmission in the central nervous system (CNS) largely relies on the actions of gamma aminobutyric acid (GABA) on GABAA receptors, heteropentameric ligand-gated chloride channels assembled from 19 possible subunits (α1-6, β1-3, γ1-3, δ,
Rueda, Diana Carolina
core   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

Scientific Reports, 2017
Aminoquinoline derivatives were evaluated against a panel of receptors/channels/transporters in radioligand binding experiments. One of these derivatives (DCUK-OEt) displayed micromolar affinity for brain γ-aminobutyric acid type A (GABAA) receptors ...
Cecilia M. Borghese, Melissa Herman, Lawrence D. Snell, Keri J. Lawrence, Hyun-Young Lee, Donald S. Backos, Lauren A. Vanderlinden, R. Adron Harris, Marisa Roberto, Paula L. Hoffman, Boris Tabakoff   +10 more
doaj   +1 more source

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABAA receptor gamma2 subunit in the cerebellum

Frontiers in Pharmacology, 2016
Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the receptor,
Elli Leppä, Anni-Maija Tuulikki Linden, M. Isabel Aller, Peer Wulff, Olga Vekovischeva, Bernhard Lüscher, Hartmut Lüddens, William Wisden, Esa R Korpi   +8 more
doaj   +1 more source

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
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Knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice

Nature Communications, 2022
Uygun et al. show that deletion of GABAA receptors from the thalamic reticular nucleus using CRISPR gene editing in mice boosts the delta waves, indicating a role for GABAA receptors on thalamic reticular nucleus neurons in NREM sleep delta oscillations.
David S. Uygun, Chun Yang, Elena R. Tilli, Fumi Katsuki, Erik L. Hodges, James T. McKenna, James M. McNally, Ritchie E. Brown, Radhika Basheer   +8 more
doaj   +1 more source

Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients. [PDF]

PLoS ONE, 2015
Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability.
Charlotte D'Hulst, Inge Heulens, Nathalie Van der Aa, Karolien Goffin, Michel Koole, Kathleen Porke, Marc Van De Velde, Liesbeth Rooms, Wim Van Paesschen, Hilde Van Esch, Koen Van Laere, R Frank Kooy   +11 more
doaj   +1 more source

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse [PDF]

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Isabel Dean, Frances A. Edwards, Dean, I., Susan J. Robertson, Edwards, F.A., Robertson, S.J.   +5 more
core   +1 more source

Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease

Neurobiology of Disease, 2012
Growing evidence suggests that Huntington's disease (HD), a neurodegenerative movement disorder caused by the mutant huntingtin (htt) with an expanded polyglutamine (polyQ) repeat, is associated with the altered intracellular trafficking and synaptic ...
Eunice Y. Yuen, Jing Wei, Ping Zhong, Zhen Yan   +3 more
doaj   +1 more source