Results 21 to 30 of about 582,495 (272)

Two Distinct Populations of α1α6-Containing GABAA-Receptors in Rat Cerebellum

Frontiers in Synaptic Neuroscience, 2020
GABAA receptors are pentameric GABA-gated chloride channels. The existence of 19 different subunits (six α, three β, three γ, δ, ε, θ, π, and three ρ) in mammalian systems gives rise to an enormous theoretical diversity of GABAA receptor subtypes with ...
Petra Scholze, Michael Pökl, Severin Längle, Friederike Steudle, Jure Fabjan, Margot Ernst   +5 more
doaj   +1 more source

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
Topf, Maya, Hannan, S, Topf, M, Smart, T.G., Baker, JR, Iqbal, F, Iqbal, F., Baker, J.R., Hannan, S., Mortensen, M, Huckvale, R, Pandurangan, Arun, Pandurangan, AP, Huckvale, R., Mortensen, M., Smart, TG   +15 more
core   +1 more source

PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
Guang Yang, Wen-Hao Dong, Chang-Long Hu, Yan-Ai Mei   +3 more
doaj   +1 more source

GABAA Receptor Subunits in Rat Testis and Sperm [PDF]

International Journal of Fertility and Sterility, 2008
Background γ-Aminobutyric acid (GABA) is considered to be the predominant inhibitory neurotransmitter in mammalian central nervous systems (CNS). There are two major classes of GABA receptors: GABAARs and GABABRs.
Abolghasem Esmaeili
doaj   +1 more source

Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAA and GABAB receptors

Reproductive Medicine and Biology, 2023
Purpose Several widely used substances (e.g., some therapeutics or food supplements) can act on gamma‐aminobutyric acid (GABA) receptors, and we investigated whether the activation of these receptors could affect the preimplantation embryo.
Veronika Kovaříková, Alexandra Špirková, Zuzana Šefčíková, Jozef Pisko, Laura Kalatová, Juraj Koppel, Dušan Fabian, Štefan Čikoš   +7 more
doaj   +1 more source

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

eLife, 2021
Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize ...
Taisuke Miyazaki, Megumi Morimoto-Tomita, Coralie Berthoux, Kotaro Konno, Yoav Noam, Tokiwa Yamasaki, Matthijs Verhage, Pablo E Castillo, Masahiko Watanabe, Susumu Tomita   +9 more
doaj   +1 more source

GABA potency at GABAA receptors found in synaptic and extrasynaptic zones

Frontiers in Cellular Neuroscience, 2012
The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen, Bijal ePatel, Trevor G. Smart   +2 more
doaj   +1 more source

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]

, 2013
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B, Belelli, D., Wlodarczyk, A. I., Sylantyev, S., Linthorst, Astrid C.E., Walker, Matthew C., Walker, M. C., Rusakov, Dmitri A, Lambert, Jeremy J, Wlodarczyk, Agnieszka I., Kersanté, Flavie, Walker, Matthew C, Semyanov, A., Semyanov, Alexey, Rusakov, Dmitri A., Rusakov, D. A., Herd, Murray B., Linthorst, A. C. E., Lambert, Jeremy J., Pavlov, I., Linthorst, Astrid C E, Lambert, J. J., Herd, M. B., Kersante, F., Wlodarczyk, Agnieszka I, Pavlov, Ivan, Sylantyev, Sergiy, Belelli, Delia   +27 more
core   +1 more source

Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.

PLoS ONE, 2014
GABAA receptors distributed in somatodendritic compartments play critical roles in regulating neuronal activities, including spike timing and firing pattern; however, the properties and functions of GABAA receptors at the axon are still poorly understood.
Yang Xia, Yuan Zhao, Mingpo Yang, Shaoqun Zeng, Yousheng Shu   +4 more
doaj   +1 more source

Extrasynaptic α6 subunit-containing GABAA receptors modulate excitability in turtle spinal motoneurons.

PLoS ONE, 2014
Motoneurons are furnished with a vast repertoire of ionotropic and metabotropic receptors as well as ion channels responsible for maintaining the resting membrane potential and involved in the regulation of the mechanisms underlying its membrane ...
Carmen Andres, Justo Aguilar, Ricardo González-Ramírez, David Elias-Viñas, Ricardo Felix, Rodolfo Delgado-Lezama   +5 more
doaj   +1 more source