Results 11 to 20 of about 39,325 (214)
Artificial intelligence in the assessment of epilepsy-related genetic mutations: Learned from GABA<sub>A</sub> receptors and GABA transporter 1. [PDF]
Epilepsia OpenAbstract This review examines how recent genetic and technological advances have transformed our understanding and treatment of genetic epilepsies (GEs), with a focus on disorders involving GABAA receptors (GABRs) and the GABA transporter 1 (GAT‐1) encoded by SLC6A1.
Wang J, Kang JQ.
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PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway
Cellular Physiology and Biochemistry, 2015 Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
Guang Yang +3 more
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Reproductive Medicine and Biology, 2023 Purpose Several widely used substances (e.g., some therapeutics or food supplements) can act on gamma‐aminobutyric acid (GABA) receptors, and we investigated whether the activation of these receptors could affect the preimplantation embryo.
Veronika Kovaříková +7 more
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Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo
eLife, 2021 Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize ...
Taisuke Miyazaki +9 more
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GABA potency at GABAA receptors found in synaptic and extrasynaptic zones
Frontiers in Cellular Neuroscience, 2012 The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen +2 more
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Frontiers in Cellular Neuroscience, 2015 GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang +8 more
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Characterization of zebrafish GABAA receptor subunits
Scientific Reports, 2021 γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, exerts its effect through the activation of GABA receptors. GABAA receptors are ligand-gated chloride channels composed of five subunit proteins.
Kenichiro Sadamitsu +5 more
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Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
PLoS ONE, 2014 GABAA receptors distributed in somatodendritic compartments play critical roles in regulating neuronal activities, including spike timing and firing pattern; however, the properties and functions of GABAA receptors at the axon are still poorly understood.
Yang Xia +4 more
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PLoS ONE, 2014 Motoneurons are furnished with a vast repertoire of ionotropic and metabotropic receptors as well as ion channels responsible for maintaining the resting membrane potential and involved in the regulation of the mechanisms underlying its membrane ...
Carmen Andres +5 more
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Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABA<sub>A</sub> Receptors in a Rat Double-Hit Stress Model. [PDF]
Pharmacol Res PerspectA double‐hit stress model in Sprague–Dawley rats induces alterations in motivation, motor impulsivity, and social recognition that are partially ameliorated by α5‐ and α6‐GABAA receptor modulation, suggesting domain‐specific effects of this modulation on the stress‐induced phenotype. ABSTRACT Impulsivity is an understudied area of post‐traumatic stress
Đorović Đ +8 more
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