Results 41 to 50 of about 582,495 (272)
Novel positive allosteric modulators of GABAA receptors with anesthetic activity. [PDF]
, 2016 GABAA receptors are the main inhibitory neurotransmitter receptors in the brain and are targets for numerous clinically important drugs such as benzodiazepines, anxiolytics and anesthetics.
Sigel, Erwin +5 more
core +2 more sources
Role of GABA receptors in fetal lung development in rats. [PDF]
PLoS ONE, 2010 Fluid accumulation is critical for lung distension and normal development. The multi-subunit γ-amino butyric acid type A receptors (GABAA) mainly act by mediating chloride ion (Cl-) fluxes.
Narendranath Reddy Chintagari +5 more
doaj +1 more source
, 2021 Objectives:This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABAA receptor density in the brains of rats in pentyleneterazole induced kindling.Methods:The rats were divided into three groups: Control group ...
Mukaddes ESREFOGLU +6 more
core +1 more source
γ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors. [PDF]
PLoS ONE, 2013 γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABAB receptors with millimolar affinity, but also binds with much higher affinity to another site ...
William M Connelly +2 more
doaj +1 more source
Discovery of new scaffolds for GABA(A) receptor modulators from natural origin [PDF]
, 2011 Gamma-aminobutyric acid type A (GABAA) receptors are the major inhibitory neurotransmitter receptors in the central nervous system (CNS). These heteropentameric transmembrane proteins act as chloride ion channel upon activation by the endogenous ligand γ-
Zaugg, Janine Michèle
core +1 more source
Advanced Science, EarlyView.Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan +11 more
wiley +1 more source
Molecular pharmacology of an insect GABA receptor [PDF]
, 2010 Cys-loop receptors are ligand-gated ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila ...
core +2 more sources
Extrasynaptic GABAA receptors and the local regulation of sleep [PDF]
, 2012 GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the mammalian brain. Recent studies emphasise the importance of extrasynaptic GABAA receptors (i.e., GABAA-Rs located outside the synapse) in controlling the excitability of local neuronal ...
Winsky-Sommerer, Raphaelle +1 more
core +1 more source
Acta Chimica SlovenicaNeurosteroids modulate the function of γ-aminobutyric acid type A (GABAA) receptors in the brain. We showed that GABAA receptors modulate neurosteroid interactions with VDAC. GABA enhanced [3H]6-AziP labeling of VDAC in a concentration-dependent manner.
Natalia Akentieva
doaj +1 more source
Gephyrin, the enigmatic organizer at GABAergic synapses
Frontiers in Cellular Neuroscience, 2012 GABAA receptors are clustered at synaptic sites to achieve a high density of postsynaptic receptors opposite the input axonal terminals. This allows an efficient propagation of GABA mediated signals, which mostly result in neuronal inhibition.
Verena Eva Tretter +5 more
doaj +1 more source