Results 61 to 70 of about 582,495 (272)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]

, 2005
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Walker, M.C., Sperk, G., Scimemi, A., Semyanov, A., Kullmann, D.M.   +4 more
core  

In silico Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties

Frontiers in Neuroscience, 2021
The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABAA receptors and the α2δ auxiliary subunit of V-gated Ca2+ channels as putative targets because they are established as mediators of efficacious anxiolytics ...
Anton V. Malyshev, Iuliia A. Sukhanova, Alexander S. Zlobin, Alexander S. Zlobin, Alexander S. Zlobin, Alexander S. Zlobin, Vasilina R. Gedzun, Vasilina R. Gedzun, Vsevolod V. Pavshintsev, Ekaterina V. Vasileva, Arthur O. Zalevsky, Igor I. Doronin, Nikita A. Mitkin, Andrey V. Golovin, Andrey V. Golovin, Andrey V. Golovin, Maxim L. Lovat, Georgy I. Kovalev, Yurii A. Zolotarev, Askar R. Kuchumov, Gennady A. Babkin, Bernhard Luscher, Bernhard Luscher   +22 more
doaj   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Expression of GABAA receptor subunit genes in the avian song system and their role in learning and memory [PDF]

, 2010
γ-aminobutyric acid type A (GABAA) receptors are the primary mediators of inhibitory neurotransmission in the brain. In avian systems, 14 GABAA receptor subunits (α1-6; β2-β4; γ1, 2 and 4, δ and π) have been identified.
Poole, A
core  

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

Translational Psychiatry, 2023
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key inhibitory neurotransmitter in the brain, working primarily via GABAA receptors ...
Andrew J. Cutler, Gregory W. Mattingly, Vladimir Maletic   +2 more
doaj   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Role of serotonergic signaling in GABAA receptor phosphorylation and functional expression [PDF]

, 2009
γ-aminobutyric acid type-A (GABAA) receptors are heteropentameric ligand-gated chloride channels that mediate the majority of fast synaptic inhibition in the brain.
Vithlani, M.
core  

A network of autism linked genes stabilizes two pools of synaptic GABAA receptors

eLife, 2015
Changing receptor abundance at synapses is an important mechanism for regulating synaptic strength. Synapses contain two pools of receptors, immobilized and diffusing receptors, both of which are confined to post-synaptic elements.
Xia-Jing Tong, Zhitao Hu, Yu Liu, Dorian Anderson, Joshua M Kaplan   +4 more
doaj   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source