Neurosteroid involvement in threatened preterm labour
Endocrinology, Diabetes & Metabolism, 2021 Introduction The neurosteroid allopregnanolone modulates oxytocin expression in the brain, and its effects arise from its action on the GABAA receptor. Whether neurosteroid levels and the function of the GABAA receptor are involved in the risk of preterm
Sahruh Turkmen +3 more
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Discovery of new scaffolds for GABA(A) receptor modulators from natural origin [PDF]
, 2011 Gamma-aminobutyric acid type A (GABAA) receptors are the major inhibitory neurotransmitter receptors in the central nervous system (CNS). These heteropentameric transmembrane proteins act as chloride ion channel upon activation by the endogenous ligand γ-
Zaugg, Janine Michèle
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Cancer Stem Cells are Depolarized Relative to Normal Stem Cells Derived from Human Livers
Annals of Hepatology, 2017 Introduction and aim. The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC).
Wendy Bautista +3 more
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Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function
Neural Plasticity, 2015 Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss. Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a ...
Valentina Licheri +5 more
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Neurobiology of Disease, 2014 We compared the effects of three missense mutations in the GABAA receptor γ2 subunit on GABAA receptor assembly, trafficking and function in HEK293T cells cotransfected with α1, β2, and wildtype or mutant γ2 subunits.
Xuan Huang +3 more
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Role of serotonergic signaling in GABAA receptor phosphorylation and functional expression [PDF]
, 2009 γ-aminobutyric acid type-A (GABAA) receptors are heteropentameric ligand-gated chloride channels that mediate the majority of fast synaptic inhibition in the brain.
Vithlani, M.
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Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors.
PLoS ONE, 2019 GABAA receptors (GABAA-Rs) play critical roles in brain development and synchronization of neural network activity. While synaptic GABAA-Rs can exert rapid inhibition, the extrasynaptic GABAA-Rs can tonically inhibit neuronal activity due to constant ...
Li Zhou +5 more
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Structural insights into opposing actions of neurosteroids on GABAA receptors
Nature Communications, 2023 γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids.
Dagimhiwat H. Legesse +7 more
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Expression and purification of a functional heteromeric GABAA receptor for structural studies.
PLoS ONE, 2018 The GABA-gated chloride channels of the Cys-loop receptor family, known as GABAA receptors, function as the primary gatekeepers of fast inhibitory neurotransmission in the central nervous system.
Derek P Claxton, Eric Gouaux
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Expression of GABAA receptor subunit genes in the avian song system and their role in learning and memory [PDF]
, 2010 γ-aminobutyric acid type A (GABAA) receptors are the primary mediators of inhibitory neurotransmission in the brain. In avian systems, 14 GABAA receptor subunits (α1-6; β2-β4; γ1, 2 and 4, δ and π) have been identified.
Poole, A
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